Abstract
In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.
| Original language | English |
|---|---|
| Pages (from-to) | 247-251 |
| Number of pages | 5 |
| Journal | Neurological Sciences |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Multiple system atrophy
- Parkinsonism
- Progressive supranuclear palsy
- Survival
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy. / Testa, D.; Monza, D.; Ferrarini, M.; Soliveri, P.; Girotti, F.; Filippini, G.
In: Neurological Sciences, Vol. 22, No. 3, 2001, p. 247-251.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy
AU - Testa, D.
AU - Monza, D.
AU - Ferrarini, M.
AU - Soliveri, P.
AU - Girotti, F.
AU - Filippini, G.
PY - 2001
Y1 - 2001
N2 - In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.
AB - In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.
KW - Multiple system atrophy
KW - Parkinsonism
KW - Progressive supranuclear palsy
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=0035176396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035176396&partnerID=8YFLogxK
U2 - 10.1007/s100720100021
DO - 10.1007/s100720100021
M3 - Article
C2 - 11731878
AN - SCOPUS:0035176396
VL - 22
SP - 247
EP - 251
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 3
ER -