Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy

D. Testa, D. Monza, M. Ferrarini, P. Soliveri, F. Girotti, G. Filippini

Research output: Contribution to journalArticle

Abstract

In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalNeurological Sciences
Volume22
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Progressive Supranuclear Palsy
Multiple System Atrophy
Paralysis
Survival
Primary Dysautonomias
Abnormal Reflexes
Hypokinesia
Death Certificates
Levodopa
Age of Onset
Differential Diagnosis

Keywords

  • Multiple system atrophy
  • Parkinsonism
  • Progressive supranuclear palsy
  • Survival

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy. / Testa, D.; Monza, D.; Ferrarini, M.; Soliveri, P.; Girotti, F.; Filippini, G.

In: Neurological Sciences, Vol. 22, No. 3, 2001, p. 247-251.

Research output: Contribution to journalArticle

Testa, D. ; Monza, D. ; Ferrarini, M. ; Soliveri, P. ; Girotti, F. ; Filippini, G. / Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy. In: Neurological Sciences. 2001 ; Vol. 22, No. 3. pp. 247-251.
@article{2df89ef0d4b34be99f44a55716e16cd9,
title = "Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy",
abstract = "In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29{\%} for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89{\%} of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.",
keywords = "Multiple system atrophy, Parkinsonism, Progressive supranuclear palsy, Survival",
author = "D. Testa and D. Monza and M. Ferrarini and P. Soliveri and F. Girotti and G. Filippini",
year = "2001",
doi = "10.1007/s100720100021",
language = "English",
volume = "22",
pages = "247--251",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "3",

}

TY - JOUR

T1 - Comparison of natural histories of progressive supranuclear palsy and multiple system atrophy

AU - Testa, D.

AU - Monza, D.

AU - Ferrarini, M.

AU - Soliveri, P.

AU - Girotti, F.

AU - Filippini, G.

PY - 2001

Y1 - 2001

N2 - In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.

AB - In order to identify early clinical features and survival predictors of supranuclear palsy (PSP) and multiple system atrophy (MSA), we compared the disease course of patients consecutively referred between 1987 and 1999 and followed to December 1999. Thirty-nine PSP and 74 MSA patients were diagnosed according to commonly accepted clinical criteria. Length of survival was ascertained from death certificates or by contacting relatives. Ten-year survival after disease onset was 29% for both disorders. Median survival was 7.0 years (PSP) and 7.5 (MSA). Neither age, symptoms at onset, or disability at diagnosis predicted survival. At diagnosis, all PSP patients had oculomotor palsy, whereas 89% of MSA patients had dysautonomia; bradykinesia and falls were the most frequent common signs. Distinctive early signs were palilalia, cognitive impairment and hyperreflexia in PSP; hypophonia, anterocollis and dysautonomia in MSA. MSA patients responded better to levodopa. Attention to early distinctive features can improve differential diagnosis and inform subsequent management.

KW - Multiple system atrophy

KW - Parkinsonism

KW - Progressive supranuclear palsy

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=0035176396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035176396&partnerID=8YFLogxK

U2 - 10.1007/s100720100021

DO - 10.1007/s100720100021

M3 - Article

C2 - 11731878

AN - SCOPUS:0035176396

VL - 22

SP - 247

EP - 251

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 3

ER -