Comparison of non-HDL-cholesterol versus triglycerides-to-HDL-cholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children: The CARITALY study

P. Di Bonito, G. Valerio, G. Grugni, M. R. Licenziati, C. Maffeis, M. Manco, E. Miraglia del Giudice, L. Pacifico, M. C. Pellegrin, M. Tomat, M. G. Baroni, Driul Daniela, Chiesa Claudio, Grandone Anna, Incani Michela, Morandi Anita, Rosa Luciano, Sanguigno Eduardo, Sartorio Alessandro, Tornese Gianluca

Research output: Contribution to journalArticle

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Abstract

Background and aims: Lipid ratios to estimate atherosclerotic disease risk in overweight/obese children are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obese children. Methods and results: In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78%) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. Conclusions: In an outpatient setting of overweight/obese children, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH.

Original languageEnglish
Pages (from-to)489-494
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume25
Issue number5
DOIs
Publication statusPublished - May 1 2015

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HDL Cholesterol
Triglycerides
Cholesterol
Carotid Intima-Media Thickness
Left Ventricular Hypertrophy
Fatty Liver
Outpatients
Obesity
Morbid Obesity
Carotid Arteries
Echocardiography
Insulin Resistance
Cross-Sectional Studies
Odds Ratio
Blood Pressure
Hypertension
Lipids
Liver
lipoprotein cholesterol

Keywords

  • Cardiometabolic risk
  • Children
  • Lipoproteins
  • Obesity complications

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Comparison of non-HDL-cholesterol versus triglycerides-to-HDL-cholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children : The CARITALY study. / Di Bonito, P.; Valerio, G.; Grugni, G.; Licenziati, M. R.; Maffeis, C.; Manco, M.; Miraglia del Giudice, E.; Pacifico, L.; Pellegrin, M. C.; Tomat, M.; Baroni, M. G.; Daniela, Driul; Claudio, Chiesa; Anna, Grandone; Michela, Incani; Anita, Morandi; Luciano, Rosa; Eduardo, Sanguigno; Alessandro, Sartorio; Gianluca, Tornese.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 25, No. 5, 01.05.2015, p. 489-494.

Research output: Contribution to journalArticle

Di Bonito, P. ; Valerio, G. ; Grugni, G. ; Licenziati, M. R. ; Maffeis, C. ; Manco, M. ; Miraglia del Giudice, E. ; Pacifico, L. ; Pellegrin, M. C. ; Tomat, M. ; Baroni, M. G. ; Daniela, Driul ; Claudio, Chiesa ; Anna, Grandone ; Michela, Incani ; Anita, Morandi ; Luciano, Rosa ; Eduardo, Sanguigno ; Alessandro, Sartorio ; Gianluca, Tornese. / Comparison of non-HDL-cholesterol versus triglycerides-to-HDL-cholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children : The CARITALY study. In: Nutrition, Metabolism and Cardiovascular Diseases. 2015 ; Vol. 25, No. 5. pp. 489-494.
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abstract = "Background and aims: Lipid ratios to estimate atherosclerotic disease risk in overweight/obese children are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obese children. Methods and results: In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78{\%}) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. Conclusions: In an outpatient setting of overweight/obese children, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH.",
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T1 - Comparison of non-HDL-cholesterol versus triglycerides-to-HDL-cholesterol ratio in relation to cardiometabolic risk factors and preclinical organ damage in overweight/obese children

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AU - Di Bonito, P.

AU - Valerio, G.

AU - Grugni, G.

AU - Licenziati, M. R.

AU - Maffeis, C.

AU - Manco, M.

AU - Miraglia del Giudice, E.

AU - Pacifico, L.

AU - Pellegrin, M. C.

AU - Tomat, M.

AU - Baroni, M. G.

AU - Daniela, Driul

AU - Claudio, Chiesa

AU - Anna, Grandone

AU - Michela, Incani

AU - Anita, Morandi

AU - Luciano, Rosa

AU - Eduardo, Sanguigno

AU - Alessandro, Sartorio

AU - Gianluca, Tornese

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background and aims: Lipid ratios to estimate atherosclerotic disease risk in overweight/obese children are receiving great attention. We aimed to compare the performance of non-high-density lipoprotein-cholesterol (HDL-C) versus triglycerides-to-HDL-C ratio (Tg/HDL-C) in identifying cardiometabolic risk factors (CMRFs) or preclinical signs of organ damage in outpatient Italian overweight/obese children. Methods and results: In this retrospective, cross-sectional study, 5505 children (age 5-18 years) were recruited from 10 Italian centers for the care of obesity, of which 4417 (78%) showed obesity or morbid obesity. Anthropometric, biochemical, and blood pressure variables were analyzed in all children. Liver ultrasound scan, carotid artery ultrasound, and echocardiography were performed in 1257, 601, and 252 children, respectively. The entire cohort was divided based on the 75th percentile of non-HDL-C (≥130mg/dl) or Tg/HDL-C ratio (≥2.2). The odds ratio for insulin resistance, high blood pressure, metabolic syndrome, presence of liver steatosis, increased levels of carotid intima-media thickness (cIMT) and concentric left ventricular hypertrophy (cLVH) was higher in children with high levels of Tg/HDL-C with respect to children with high levels of non-HDL-C. Conclusions: In an outpatient setting of overweight/obese children, Tg/HDL-C ratio discriminated better than non-HDL-C children with CMRFs or preclinical signs of liver steatosis, and increased cIMT and cLVH.

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KW - Children

KW - Lipoproteins

KW - Obesity complications

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