Comparison of on pump and off pump coronary surgery: risk factors for neurological outcome

Erminio Sisillo, Maria Rosaria Marino, Glauco Juliano, Cristina Beverini, Luca Salvi, Francesco Alamanni

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Cerebrovascular accidents (CVA) are devastating complications after coronary artery bypass grafting (CABG). The reported incidence of neurological complications after conventional CABG (CCABG) is 3-6%. Off-pump coronary bypass grafting (OPCAB) has been associated in recent studies to a decreased morbidity and risk of perioperative stroke. Nevertheless, uncertainty still surrounds the relative benefits of OPCAB. We investigated whether, in our experience, OPCAB was associated with lower neurological morbidity than conventional CABG approach. Methods: Eight thousand and two patients underwent isolated CABG at our institution between January 1998 and January 2005. OPCAB operation was performed on 1415 patients. Data were prospectively collected. A multiple logistic regression analysis was used to evaluate the influence of the two different surgical techniques on the neurological outcomes. Results: Patients in the OPCAB group were significantly older (66.2 vs 63.5%, p <0.0001), had a higher incidence of renal injury (5.4 vs 2.4%, p <0.0001), and were more redo interventions (6.95 vs 1.53%, p <0.0001). The CCABG patients were more urgent at operation (5.46 vs 3.26, p = 0.0007), were less hypertensive (57.6 vs 63% of the patients, p = 0.0003) more diabetics (22 vs 20.6%, NS), and had an ejection fraction less than 0.40 (10.4 vs 9.6%, NS). CVA incidence was similar in both groups (Type I outcome: OPCAB = 0.70% vs CCABG = 0.68%, p = 0.91; Type II outcome OPCAB = 0.70% vs CCABG = 0.83%, p = 0.63). Conclusions: In our experience patients undergoing CCABG were not exposed to a grater risk of neurological adverse events when compared to OPCAB patients.

Original languageEnglish
Pages (from-to)1076-1080
Number of pages5
JournalEuropean Journal of Cardio-thoracic Surgery
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Coronary Artery Bypass
Stroke
Incidence
Morbidity
Uncertainty
Logistic Models
Regression Analysis
Kidney
Wounds and Injuries

Keywords

  • Cardiopulmonary bypass
  • Cerebrovascular accidents
  • Neurological outcomes
  • Off pump cardiac surgery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Comparison of on pump and off pump coronary surgery : risk factors for neurological outcome. / Sisillo, Erminio; Marino, Maria Rosaria; Juliano, Glauco; Beverini, Cristina; Salvi, Luca; Alamanni, Francesco.

In: European Journal of Cardio-thoracic Surgery, Vol. 31, No. 6, 06.2007, p. 1076-1080.

Research output: Contribution to journalArticle

Sisillo, Erminio ; Marino, Maria Rosaria ; Juliano, Glauco ; Beverini, Cristina ; Salvi, Luca ; Alamanni, Francesco. / Comparison of on pump and off pump coronary surgery : risk factors for neurological outcome. In: European Journal of Cardio-thoracic Surgery. 2007 ; Vol. 31, No. 6. pp. 1076-1080.
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abstract = "Objective: Cerebrovascular accidents (CVA) are devastating complications after coronary artery bypass grafting (CABG). The reported incidence of neurological complications after conventional CABG (CCABG) is 3-6{\%}. Off-pump coronary bypass grafting (OPCAB) has been associated in recent studies to a decreased morbidity and risk of perioperative stroke. Nevertheless, uncertainty still surrounds the relative benefits of OPCAB. We investigated whether, in our experience, OPCAB was associated with lower neurological morbidity than conventional CABG approach. Methods: Eight thousand and two patients underwent isolated CABG at our institution between January 1998 and January 2005. OPCAB operation was performed on 1415 patients. Data were prospectively collected. A multiple logistic regression analysis was used to evaluate the influence of the two different surgical techniques on the neurological outcomes. Results: Patients in the OPCAB group were significantly older (66.2 vs 63.5{\%}, p <0.0001), had a higher incidence of renal injury (5.4 vs 2.4{\%}, p <0.0001), and were more redo interventions (6.95 vs 1.53{\%}, p <0.0001). The CCABG patients were more urgent at operation (5.46 vs 3.26, p = 0.0007), were less hypertensive (57.6 vs 63{\%} of the patients, p = 0.0003) more diabetics (22 vs 20.6{\%}, NS), and had an ejection fraction less than 0.40 (10.4 vs 9.6{\%}, NS). CVA incidence was similar in both groups (Type I outcome: OPCAB = 0.70{\%} vs CCABG = 0.68{\%}, p = 0.91; Type II outcome OPCAB = 0.70{\%} vs CCABG = 0.83{\%}, p = 0.63). Conclusions: In our experience patients undergoing CCABG were not exposed to a grater risk of neurological adverse events when compared to OPCAB patients.",
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T2 - risk factors for neurological outcome

AU - Sisillo, Erminio

AU - Marino, Maria Rosaria

AU - Juliano, Glauco

AU - Beverini, Cristina

AU - Salvi, Luca

AU - Alamanni, Francesco

PY - 2007/6

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N2 - Objective: Cerebrovascular accidents (CVA) are devastating complications after coronary artery bypass grafting (CABG). The reported incidence of neurological complications after conventional CABG (CCABG) is 3-6%. Off-pump coronary bypass grafting (OPCAB) has been associated in recent studies to a decreased morbidity and risk of perioperative stroke. Nevertheless, uncertainty still surrounds the relative benefits of OPCAB. We investigated whether, in our experience, OPCAB was associated with lower neurological morbidity than conventional CABG approach. Methods: Eight thousand and two patients underwent isolated CABG at our institution between January 1998 and January 2005. OPCAB operation was performed on 1415 patients. Data were prospectively collected. A multiple logistic regression analysis was used to evaluate the influence of the two different surgical techniques on the neurological outcomes. Results: Patients in the OPCAB group were significantly older (66.2 vs 63.5%, p <0.0001), had a higher incidence of renal injury (5.4 vs 2.4%, p <0.0001), and were more redo interventions (6.95 vs 1.53%, p <0.0001). The CCABG patients were more urgent at operation (5.46 vs 3.26, p = 0.0007), were less hypertensive (57.6 vs 63% of the patients, p = 0.0003) more diabetics (22 vs 20.6%, NS), and had an ejection fraction less than 0.40 (10.4 vs 9.6%, NS). CVA incidence was similar in both groups (Type I outcome: OPCAB = 0.70% vs CCABG = 0.68%, p = 0.91; Type II outcome OPCAB = 0.70% vs CCABG = 0.83%, p = 0.63). Conclusions: In our experience patients undergoing CCABG were not exposed to a grater risk of neurological adverse events when compared to OPCAB patients.

AB - Objective: Cerebrovascular accidents (CVA) are devastating complications after coronary artery bypass grafting (CABG). The reported incidence of neurological complications after conventional CABG (CCABG) is 3-6%. Off-pump coronary bypass grafting (OPCAB) has been associated in recent studies to a decreased morbidity and risk of perioperative stroke. Nevertheless, uncertainty still surrounds the relative benefits of OPCAB. We investigated whether, in our experience, OPCAB was associated with lower neurological morbidity than conventional CABG approach. Methods: Eight thousand and two patients underwent isolated CABG at our institution between January 1998 and January 2005. OPCAB operation was performed on 1415 patients. Data were prospectively collected. A multiple logistic regression analysis was used to evaluate the influence of the two different surgical techniques on the neurological outcomes. Results: Patients in the OPCAB group were significantly older (66.2 vs 63.5%, p <0.0001), had a higher incidence of renal injury (5.4 vs 2.4%, p <0.0001), and were more redo interventions (6.95 vs 1.53%, p <0.0001). The CCABG patients were more urgent at operation (5.46 vs 3.26, p = 0.0007), were less hypertensive (57.6 vs 63% of the patients, p = 0.0003) more diabetics (22 vs 20.6%, NS), and had an ejection fraction less than 0.40 (10.4 vs 9.6%, NS). CVA incidence was similar in both groups (Type I outcome: OPCAB = 0.70% vs CCABG = 0.68%, p = 0.91; Type II outcome OPCAB = 0.70% vs CCABG = 0.83%, p = 0.63). Conclusions: In our experience patients undergoing CCABG were not exposed to a grater risk of neurological adverse events when compared to OPCAB patients.

KW - Cardiopulmonary bypass

KW - Cerebrovascular accidents

KW - Neurological outcomes

KW - Off pump cardiac surgery

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