Comparison of Outcomes of Transcatheter Aortic Valve Implantation in Patients ≥85 Years Versus Those

Martino Pepe, Nicola Corcione, Giuseppe Biondi-Zoccai, Alberto Morello, Sergio Berti, Francesco Bedogni, Alessandro Iadanza, Fabrizio Tomai, Gennaro Sardella, Enrico Romagnoli, Paolo Ferraro, Sirio Conte, Palma Luisa Nestola, Marcello De Giosa, Michele Cimmino, Giacomo Frati, Arturo Giordano

Research output: Contribution to journalArticlepeer-review


The differential outcomes across the age spectrum of transcatheter aortic valve implantation (TAVI) recipients are still debated. Aim of the study was to evaluate the clinical outcomes of oldest-old patients undergoing TAVI in the large "Registro Italiano GISE sull'impianto di Valvola Aortica Percutanea (RISPEVA)" registry. A total of 3,507 patients were stratified according to age: 1,381 were ≥85 years, 2,126 were <85 years. Primary endpoints were death at 30-days and complete follow-up (FU) (medium 368 days). Cerebrovascular events, myocardial infarction, bleedings, vascular complications at 30-days and complete FU were considered. In the unadjusted analysis, 30-days mortality in the oldest-old group was higher than in younger patients (4.2% vs 2.4%; p = 0.007); this difference kept true also at complete FU (19.6% vs 15.9%; p = 0.014). After propensity score (PS) matching, the oldest-old population showed a higher mortality solely at 30-days (4.7% vs 2.4%; p = 0.016), while the survival at complete FU was similar to that of younger patients (20.1% vs 18.0%; p = 0.286). The incidence of non-fatal outcomes resulted comparable between the 2 groups, also after propensity score matching. At the multivariate logistic regression analysis procedural major or disabling bleedings, cerebrovascular events, cardiogenic shock resulted predictors of 30-days death in the oldest-old cohort. In conclusion, patients ≥85 years can safely undergo TAVI being not more exposed to procedural complications than those <85 years; nevertheless they showed worse 30-days mortality, probably driven by reduced tolerance to complications. Passed the critical periprocedural phase, patients ≥85 years had a similar survival to those <85 years with comparable risk profile.

Original languageEnglish
JournalThe American Journal of Cardiology
Publication statusE-pub ahead of print - May 26 2020


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