Comparison of peginterferon pharmacokinetic and pharmacodynamic profiles

R. Bruno, P. Sacchi, S. Cima, L. Maiocchi, S. Novati, G. Filice, S. Fagiuoli

Research output: Contribution to journalArticlepeer-review

Abstract

The pharmacokinetics and in dosing regimens of the currently available pegylated interferon (peginterferon) alfa molecules differ greatly, depending on the size and nature of their polyethylene glycol (PEG) moiety. Peginterferon alfa-2a has a branched 40 kDa PEG chain covalently attached to lysine residues and circulates as an intact molecule. On the other hand, peginterferon alfa-2b has a linear 12 kDa PEG chain covalently attached to interferon-a-2b via an unstable urethane bond that is hydrolysed after injection, releasing native interferon alfa-2b. The difference in pegylation between the two peginterferons has a significant impact on their pharmacokinetic properties. Data from comparative and non-comparative studies indicate that peginterferon alfa-2b has a shorter half-life in serum than peginterferon alfa-2a, and a significant proportion of patients receiving peginterferon alfa-2b may have trough concentrations below the limit of detection during the latter part of the 7-day dosing schedule. However, the pharmacodynamic parameters of the two drugs appear to be similar.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalJournal of Viral Hepatitis
Volume19
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • HCV
  • peginterferon
  • pharmacodynamic
  • pharmacokinetic

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases
  • Virology

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