Comparison of propofol versus propofol-ketamine combination in pediatric oncologic procedures performed by non-anesthesiologists

Antonio Chiaretti, Antonio Ruggiero, Egidio Barbi, Filomena Pierri, Palma Maurizi, Claudia Fantacci, Giulia Bersani, Riccardo Riccardi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Limited data are available on the best option (short acting sedatives, opioids, or ketamine) in oncologic procedural sedation performed by non-anesthesiologists. The aim of the present prospective study is to compare the safety and efficacy of propofol-ketamine versus propofol alone, managed by trained pediatricians, in children with cancer undergoing painful procedures. Procedures: Data on 121 children with acute lymphatic leukemia (ALL) undergoing procedural sedations (lumbar punctures and bone marrow aspirations) were prospectively collected and included drug doses, side effects, pain assessment, and sedation degree. Children were randomly assigned to one of the two groups: P (n=62) receiving propofol alone and K (n=59) in whom a ketamine-propofol combination was used. Results: In group K, the total dose of propofol required was significantly lower than in group P (3.9±3.6mg/kg vs. 5.1±3.6mg/kg; P2 desaturations (defined as SatO 2

Original languageEnglish
Pages (from-to)1163-1167
Number of pages5
JournalPediatric Blood and Cancer
Volume57
Issue number7
DOIs
Publication statusPublished - Dec 15 2011

Keywords

  • Children
  • Ketamine
  • Non-anesthesiologist procedural sedation
  • Propofol

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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