Comparison of propofol versus propofol-ketamine combination in pediatric oncologic procedures performed by non-anesthesiologists

Antonio Chiaretti; Antonio Ruggiero; Egidio Barbi; Filomena Pierri; Palma Maurizi; Claudia Fantacci; Giulia Bersani; Riccardo Riccardi

doi:10.1002/pbc.23170

Comparison of propofol versus propofol-ketamine combination in pediatric oncologic procedures performed by non-anesthesiologists

Antonio Chiaretti, Antonio Ruggiero, Egidio Barbi, Filomena Pierri, Palma Maurizi, Claudia Fantacci, Giulia Bersani, Riccardo Riccardi

IRCCS pediatrico Burlo Garofolo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Limited data are available on the best option (short acting sedatives, opioids, or ketamine) in oncologic procedural sedation performed by non-anesthesiologists. The aim of the present prospective study is to compare the safety and efficacy of propofol-ketamine versus propofol alone, managed by trained pediatricians, in children with cancer undergoing painful procedures. Procedures: Data on 121 children with acute lymphatic leukemia (ALL) undergoing procedural sedations (lumbar punctures and bone marrow aspirations) were prospectively collected and included drug doses, side effects, pain assessment, and sedation degree. Children were randomly assigned to one of the two groups: P (n=62) receiving propofol alone and K (n=59) in whom a ketamine-propofol combination was used. Results: In group K, the total dose of propofol required was significantly lower than in group P (3.9±3.6mg/kg vs. 5.1±3.6mg/kg; P2 desaturations (defined as SatO ₂

Original language	English
Pages (from-to)	1163-1167
Number of pages	5
Journal	Pediatric Blood and Cancer
Volume	57
Issue number	7
DOIs	https://doi.org/10.1002/pbc.23170
Publication status	Published - Dec 15 2011

Keywords

Children
Ketamine
Non-anesthesiologist procedural sedation
Propofol

ASJC Scopus subject areas

Oncology
Pediatrics, Perinatology, and Child Health
Hematology

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Comparison of propofol versus propofol-ketamine combination in pediatric oncologic procedures performed by non-anesthesiologists. / Chiaretti, Antonio; Ruggiero, Antonio; Barbi, Egidio; Pierri, Filomena; Maurizi, Palma; Fantacci, Claudia; Bersani, Giulia; Riccardi, Riccardo.

In: Pediatric Blood and Cancer, Vol. 57, No. 7, 15.12.2011, p. 1163-1167.

Research output: Contribution to journal › Article › peer-review

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