Comparison of protease genotype and phenotype in HIV-1 infected patients exposed to more than one protease inhibitor

N. Gianotti, G. Tambussi, E. Boeri, A. Lazzarin

Research output: Contribution to journalArticlepeer-review

Abstract

Many patterns of mutations selected by HIV-1 protease inhibitors have been described, but in most cases isolates with these patterns have been obtained from pre-clinical studies or after failures of monotherapies. We compared genotype and phenotype in HIV-1 infected patients who have failed more than one P1-including regimen. Phenotypic resistance could arise also in the absence of specific primary mutations and in the presence of different substitutions among those known to confer resistance to ritonavir, indinavir or nelfinavir. The number of secondary mutations was significantly associated with phenotypic resistance for each protease inhibitor. Thus, more study of mutational patterns in heavily pretreated patients is warranted; in the mean time treatment choices might be optimized if phenotyping could integrate genotyping within this setting.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Volume15
Issue number2
Publication statusPublished - 2001

Keywords

  • Antiretroviral therapy
  • Genotype
  • HIV
  • Phenotype
  • Protease inhibitors
  • Resistance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)

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