The time course of quinidine plasma concentrations and selected kinetic parameters were studied in healthy male volunteers given single oral doses of 4 different quinidine formulations. Comparison was made with quinidine sulfate in a rapidly dissolving form. Plasma half lives did not significantly differ among treatments. Quinidine polygalacturonate appears to be equivalent to quinidine sulfate in respect to both the absorption and elimination kinetics. When both quinidine bisulfate (Kinidin Durules) and quinidine arabogalactansulfate (Longacor) were administered plasma levels peaked significantly later than after quinidine sulfate. However, while the former seems to be absorbed to the same extent as quinidine sulfate, the latter exhibits lower bioavailability in respect to all other preparations. Therapeutic relevance of such observations is discussed.
|Number of pages||6|
|Journal||British Journal of Clinical Pharmacology|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)