Comparison of quinidine plasma concentration curves following oral administration of some short- and long-acting formulations

G. M. Frigo, E. Perucca, M. Teggia-Droghi, G. Gatti, A. Mussini, J. Salerno

Research output: Contribution to journalArticlepeer-review

Abstract

The time course of quinidine plasma concentrations and selected kinetic parameters were studied in healthy male volunteers given single oral doses of 4 different quinidine formulations. Comparison was made with quinidine sulfate in a rapidly dissolving form. Plasma half lives did not significantly differ among treatments. Quinidine polygalacturonate appears to be equivalent to quinidine sulfate in respect to both the absorption and elimination kinetics. When both quinidine bisulfate (Kinidin Durules) and quinidine arabogalactansulfate (Longacor) were administered plasma levels peaked significantly later than after quinidine sulfate. However, while the former seems to be absorbed to the same extent as quinidine sulfate, the latter exhibits lower bioavailability in respect to all other preparations. Therapeutic relevance of such observations is discussed.

Original languageEnglish
Pages (from-to)449-454
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume4
Issue number4
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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