Comparison of renal function detriments after local tumor ablation or partial nephrectomy for renal cell carcinoma

Alessandro Larcher, Malek Meskawi, Roger Valdivieso, Katharina Boehm, Vincent Trudeau, Zhe Tian, Nicola Fossati, P. Dell’Oglio, Giovanni Lughezzani, Nicolò Buffi, M. Sun, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Local tumor ablation (LTA) and partial nephrectomy (PN) represent treatment alternatives for patients diagnosed with small renal mass and both may result in renal function detriments. The aim of the study was to compare renal function detriments after LTA or PN. Methods: A Surveillance epidemiology and End Results-Medicare-linked retrospective cohort of 2850 T1 kidney cancer patients who underwent LTA or PN was abstracted. Short-term outcomes consisted of 30-day acute kidney injury (AKI) and 30-day dialysis rates. Long-term outcomes consisted of episodes of AKI, mild and moderate–severe chronic kidney disease (CKD), end-stage renal disease, hemodialysis and anemia in CKD. Analyses consisted of propensity score matching, logistic and Cox regression. Results: After propensity score matching, 1122 patients remained. The 30-day incidence of AKI was 4.6 % after LTA and 9.4 % after PN. In multivariable analyses (MVAs), LTA was associated with a lower AKI rate (OR 0.42; p = 0.001). The 30-day incidence of any dialysis was 0.5). Conclusions: LTA offers short-term protective effect from AKI. The short-term rates of any dialysis treatment are similar after either LTA or PN. At long-term assessment, LTA and PN renal function detriment rates are not different. Concern for long-term functional outcomes should not be a barrier for PN.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalWorld Journal of Urology
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Acute kidney injury
  • Chronic kidney disease
  • Dialysis
  • Kidney cancer
  • Local tumor ablation
  • Nephron-sparing surgery
  • Partial nephrectomy
  • Renal function

ASJC Scopus subject areas

  • Urology

Fingerprint

Dive into the research topics of 'Comparison of renal function detriments after local tumor ablation or partial nephrectomy for renal cell carcinoma'. Together they form a unique fingerprint.

Cite this