Comparison of simultaneous 18F-2-[18F] FDG PET/MR and PET/CT in the follow-up of patients with differentiated thyroid cancer

Michele Klain, Carmela Nappi, Emanuele Nicolai, Valeria Romeo, Leandra Piscopo, Alessia Giordano, Valeria Gaudieri, Emilia Zampella, Leonardo Pace, Cavaliere Carlo, Marco Salvatore, Martin Schlumberger, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review


Aims: 18F-FDG PET/CT is the most accurate imaging modality in differentiated thyroid cancer (DTC) patients with either an aggressive histology, an absence of radioiodine uptake in neoplastic foci, or in the absence of imaging abnormalities in patients with an elevated serum thyroglobulin (Tg) level that progresses with time. We evaluated the diagnostic performance of FDG PET/MR in comparison with that of PET/CT. Methods and results: Following the injection of a single 18F-FDG activity, PET/MR and PET/CT were sequentially performed in 40 consecutive patients with DTC previously treated with total thyroidectomy and radioiodine ablation. All patients were then followed up for at least 6 months. PET/MR was positive in 11 patients and PET/CT in 10. PET/MR detected 33 tumor foci and PET/CT 30. During the follow-up of the 12 patients with negative initial PET studies and with a detectable serum Tg, only one patient had a neck recurrence and the administration of an empiric high activity of 131I in the other 11 patients did not reveal any tumor focus. In the 17 patients with an initial serum Tg level < 2 ng/mL, no recurrence occurred. Conclusion: This study confirms the high diagnostic accuracy of FDG PET studies in DTC patients with elevated serum Tg levels and shows that PET/MR brings similar information as compared to PET/CT imaging.

Original languageEnglish
Pages (from-to)3066-3073
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number13
Publication statusPublished - Dec 2020


  • Differentiated thyroid cancer
  • FDG
  • PET/CT
  • PET/MR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Comparison of simultaneous 18F-2-[18F] FDG PET/MR and PET/CT in the follow-up of patients with differentiated thyroid cancer'. Together they form a unique fingerprint.

Cite this