Comparison of spinal fluid β2-microglobulin levels with cd4+ t cell count, in vitro t helper cell function, and spinal fluid igg parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type 1

Daniel R. Lucey, Stephen A. McGuire, Mario Clerici, Kevin Hall, Jean Benton, Clifford A. Butzin, William W. Ward, Gene Shearer, R. Neal Boswell, Craig W. Hendrix

Research output: Contribution to journalArticle


β2-microglobulin levels were measured in the cerebrospinal fluid (CSF) and serum of 163 human immunodeficiency virus-positive (HIV+) persons with normal neurologic physical examinations. None were on antiretroviral therapy. Only 3% had a positive CSF HIV p24 antigen test. The CSF β2-microglobulin levels increased as the CD4+ T cell count decreased. Intrathecal production of β2-microglobulin was suggested by finding CSF concentrations greater than serum concentrations in 15% of patients. The CSF β2-microglobulin levels rose as in vitro T helper cell function deteriorated, independent of CD4+ T cell count. CSF β2-microglobulin levels paralleled CSF IgG, IgG index, and IgG synthesis. Higher CSF β2-microglobulin levels were found in persons with positive CSF oligoclonal bands. CSF β2-microglobulin concentration may serve as a marker for subclinical neurologic damage due to HIV. If this is established, defining the effect of anti-HIV interventions on CSF β2-microglobulin would be warranted.

Original languageEnglish
Pages (from-to)971-975
Number of pages5
JournalJournal of Infectious Diseases
Issue number5
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

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