Comparison of spinal fluid β2-microglobulin levels with cd4+ t cell count, in vitro t helper cell function, and spinal fluid igg parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type 1

Daniel R. Lucey, Stephen A. McGuire, Mario Clerici, Kevin Hall, Jean Benton, Clifford A. Butzin, William W. Ward, Gene Shearer, R. Neal Boswell, Craig W. Hendrix

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Abstract

β2-microglobulin levels were measured in the cerebrospinal fluid (CSF) and serum of 163 human immunodeficiency virus-positive (HIV+) persons with normal neurologic physical examinations. None were on antiretroviral therapy. Only 3% had a positive CSF HIV p24 antigen test. The CSF β2-microglobulin levels increased as the CD4+ T cell count decreased. Intrathecal production of β2-microglobulin was suggested by finding CSF concentrations greater than serum concentrations in 15% of patients. The CSF β2-microglobulin levels rose as in vitro T helper cell function deteriorated, independent of CD4+ T cell count. CSF β2-microglobulin levels paralleled CSF IgG, IgG index, and IgG synthesis. Higher CSF β2-microglobulin levels were found in persons with positive CSF oligoclonal bands. CSF β2-microglobulin concentration may serve as a marker for subclinical neurologic damage due to HIV. If this is established, defining the effect of anti-HIV interventions on CSF β2-microglobulin would be warranted.

Original languageEnglish
Pages (from-to)971-975
Number of pages5
JournalJournal of Infectious Diseases
Volume163
Issue number5
DOIs
Publication statusPublished - 1991

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Helper-Inducer T-Lymphocytes
Cerebrospinal Fluid
HIV-1
Cell Count
HIV
Immunoglobulin G
CD4 Lymphocyte Count
In Vitro Techniques
HIV Core Protein p24
Oligoclonal Bands
T-Lymphocytes
Neurologic Examination
Serum
Nervous System
Physical Examination

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Comparison of spinal fluid β2-microglobulin levels with cd4+ t cell count, in vitro t helper cell function, and spinal fluid igg parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type 1. / Lucey, Daniel R.; McGuire, Stephen A.; Clerici, Mario; Hall, Kevin; Benton, Jean; Butzin, Clifford A.; Ward, William W.; Shearer, Gene; Neal Boswell, R.; Hendrix, Craig W.

In: Journal of Infectious Diseases, Vol. 163, No. 5, 1991, p. 971-975.

Research output: Contribution to journalArticle

Lucey, Daniel R. ; McGuire, Stephen A. ; Clerici, Mario ; Hall, Kevin ; Benton, Jean ; Butzin, Clifford A. ; Ward, William W. ; Shearer, Gene ; Neal Boswell, R. ; Hendrix, Craig W. / Comparison of spinal fluid β2-microglobulin levels with cd4+ t cell count, in vitro t helper cell function, and spinal fluid igg parameters in 163 neurologically normal adults infected with the human immunodeficiency virus type 1. In: Journal of Infectious Diseases. 1991 ; Vol. 163, No. 5. pp. 971-975.
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