Comparison of steroid hormone receptors, ploidy, EGFr, HER2-neu, and cathepsin D content in healthy and tumor gastrointestinal samples

C. Zibera, N. Gibelli, P. Baiardi, S. Sforza, P. Pedrazzoli, L. Bacchella, G. Morone, M. G. Valesi, G. Robustelli Della Cuna

Research output: Contribution to journalArticlepeer-review

Abstract

Several prognostic factors, known to be useful in breast cancer, have been evaluated in healthy and tumor samples of patients affected by gastric (21 cases) and colorectal cancer (43 cases). Very low levels of estrogen and progesterone receptors (ER and PgR) were found. Proliferative activity, evaluated as S-phase of diploid cases, significantly increased in tumor samples and the incidence of aneuploid stemlines was higher in patients with C and D Astler-Coller stages. Epidermal growth factor receptor (EGFr) oncoprotein level in normal colorectal mucosa was higher than in neoplastic tissue, while in gastric tumors an inverse behaviour was observed. In these tumors an increase of HER-2/neu oncoprotein occurred in intestinal rather than in diffuse type. Among the markers studied, Cathepsin D (Cat D) appeared to be the most strongly involved in the neoplastic changes and a multivariate analysis showed that its association to HER-2/neu had the highest capacity to discriminate normal from neoplastic samples.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Volume15
Issue number4
Publication statusPublished - Dec 1996

Keywords

  • flow cytometry
  • gastrointestinal tumors
  • tumor markers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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