Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension

G. Leonetti, C. Mazzola, S. Boni, E. Guffanti, A. Meani, A. Zanchetti

Research output: Contribution to journalArticlepeer-review


The hypertensive effect of urapidil, a new antihypertensive agent that acts via central and peripheral alpha-adrenoceptors, has been compared with that of metoprolol in 40 patients with mild essential hypertension. Blood pressure was significantly reduced by both drugs, while the heart rate was reduced only after metoprolol. The increases in systolic blood pressure and heart rate caused by three progressive work loads of bicycle exercise were not affected during urapidil, whereas both were reduced by metoprolol. A slight reduction in forced expiratory volume was observed in some patients during treatment with the beta-blocker. There was no case of orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare and negligible with both drugs.

Original languageEnglish
Pages (from-to)637-640
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Issue number6
Publication statusPublished - Nov 1986


  • antihypertensive treatment
  • exercise test
  • haemodymic effects
  • metoprolol
  • side-effects
  • urapidil

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


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