Comparison of the blood pressure-lowering effects and tolerability of losartan- and amlodipine-based regimens in patients with isolated systolic hypertension

Massimo Volpe, Zhu Junren, Thomas Maxwell, Aldo Rodriguez, Raul Gamboa, Pablo Gomez-Fernandez, Ginés Ortega-Gonzalez, Norberta Matadamas, Freddy Rodriguez, Badal Dass, Chris Kyle, Laurent Clarysse, Alfonso Bryce, Ernesto Moreno-Heredia, Giuseppe Germano, Leen Gilles, Ronald D. Smith, John E. Sanderson

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Elevated systolic blood pressure is a more important risk factor for cardiovascular and renal disease than elevated diastolic blood pressure. Isolated systolic hypertension (ISH) is the predominant form of hypertension in the elderly. Effects of angiotensin II on the vascular wall and endothelium may contribute to development of ISH. Objective: The primary objective of this study was to compare the effects on trough sitting systolic blood pressure (SiSBP) of a regimen of losartan, a selective angiotensin II-receptor antagonist, and an amlodipine-based regimen in patients with ISH. Methods: This multicenter, prospective, randomized, double-blind, parallel-group study consisted of a 4-week placebo phase and an 18-week active-treatment phase. The losartan-based regimen consisted of losartan 50 mg, increased as needed to losartan 50 mg/hydrochlorothiazide (HCTZ) 12.5 mg at week 6 and to losartan 100 mg/HCTZ 25 mg at week 12 to achieve a target SiSBP

Original languageEnglish
Pages (from-to)1469-1489
Number of pages21
JournalClinical Therapeutics
Volume25
Issue number5
DOIs
Publication statusPublished - May 1 2003

Keywords

  • Angiotensin II-receptor antagonist
  • Isolated systolic hypertension
  • Losartan

ASJC Scopus subject areas

  • Pharmacology

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