Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer

Silvia Franceschi, Fabio Levi, Carlo La Vecchia, Ettore Conti, Luigino Dal Maso, Luigi Barzan, Renato Talamini

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

To compare the separate and combined effects of alcohol drinking and smoking between the 2 sites, we evaluated 274 men with oral cancer, 364 with pharyngeal cancer and 1,254 controls, frequency-matched for age and area of residence, from Italy and Switzerland. Extremely elevated risk increases for oral cancer (odds ratio, OR = 228) and pharyngeal cancer (OR = 100) were found for the highest joint level of drinking (≥ 77 drinks/week) and smoking (≥ 25 cigarettes/day). Ratios of ORs between oral cancer and pharyngeal cancer vs. controls, obtained by polytomous logistic regression, suggested that the risk increase for oral cancer was about 2-fold greater than that for pharyngeal cancer at each combined level of smoking and drinking, except at low levels of drinking in smokers. A clear departure from risk difference additivity was present for both oral and pharyngeal cancer in individuals heavily exposed to both factors versus non-smoking abstainers/light drinkers. Our findings thus help explain observations from descriptive epidemiology that, if smoking level in a population does not change substantially, but alcohol consumption increases, increase in oral cancer would be greater than at any other site in the upper aero-digestive tract, including cancer of the pharynx.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalInternational Journal of Cancer
Volume83
Issue number1
DOIs
Publication statusPublished - 1999

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Pharyngeal Neoplasms
Mouth Neoplasms
Alcohol Drinking
Smoking
Drinking
Switzerland
Italy
Gastrointestinal Tract
Epidemiology
Joints
Logistic Models
Odds Ratio
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer. / Franceschi, Silvia; Levi, Fabio; La Vecchia, Carlo; Conti, Ettore; Dal Maso, Luigino; Barzan, Luigi; Talamini, Renato.

In: International Journal of Cancer, Vol. 83, No. 1, 1999, p. 1-4.

Research output: Contribution to journalArticle

Franceschi, Silvia ; Levi, Fabio ; La Vecchia, Carlo ; Conti, Ettore ; Dal Maso, Luigino ; Barzan, Luigi ; Talamini, Renato. / Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer. In: International Journal of Cancer. 1999 ; Vol. 83, No. 1. pp. 1-4.
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