Comparison of the effect of valsartan and lisinopril on autonomic nervous system activity in chronic heart failure.

Elisabetta De Tommasi, Massimo Iacoviello, Roberta Romito, Claudio Ceconi, Pietro Guida, Francesco Massari, Gloria Francolini, Federico Bertocchi, Roberto Ferrari, Paolo Rizzon, Maria Vittoria Pitzalis

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Abstract

BACKGROUND: In chronic heart failure (CHF), the derangement of autonomic nervous system activity has a deep impact on the progression of the disease. It has been demonstrated that modulation of the renin-angiotensin aldosterone system (RAAS) increases autonomic control of heart rate and reduces adrenergic activity. We sought to evaluate, in CHF, the different effects of an ACE inhibitor (lisinopril) and of an AT1 receptor antagonist (valsartan) on heart rate variability, baroreflex sensitivity and norepinephrine plasma levels. METHODS: Ninety patients (61 +/- 10 years, 2.3 +/- 0.5, New York Heart Association class) with CHF and left ventricular ejection fraction

Original languageEnglish
JournalAmerican Heart Journal
Volume146
Issue number5
Publication statusPublished - Nov 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    De Tommasi, E., Iacoviello, M., Romito, R., Ceconi, C., Guida, P., Massari, F., Francolini, G., Bertocchi, F., Ferrari, R., Rizzon, P., & Pitzalis, M. V. (2003). Comparison of the effect of valsartan and lisinopril on autonomic nervous system activity in chronic heart failure. American Heart Journal, 146(5).