Comparison of the effectiveness of several formulations of sodium valproate: Tablets, enteric-coated capsules, solutions and rectal capsules

D. Battino, M. Biraghi, C. Cusi, A. Nespolo, G. Avanzini

Research output: Contribution to journalArticle

Abstract

The effects of an oral entericcoated preparation (VAL 579 capsules) of sodium valproate (VPA) were compared with those of conventional oral and rectal preparations in 24 epileptic patients. Entericcoated capsules are useful for avoiding gastric intolerance to VPA. Plasma VPA level peaks after the enteric-coated form were later than after other forms. The bioavailability appeared to be the same for all the forms.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalItalian Journal of Neurological Sciences
Volume3
Issue number3
DOIs
Publication statusPublished - Sep 1982

Keywords

  • antiepileptic drugs
  • plasma levels
  • Sodium valproate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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