Comparison of the Effects of Ramipril Versus Telmisartan on High-Sensitivity C-Reactive Protein and Endothelial Progenitor Cells After Acute Coronary Syndrome

Italo Porto, Luca Di Vito, Giovanni Luigi De Maria, Ilaria Dato, Alessandra Tritarelli, Antonio Maria Leone, Giampaolo Niccoli, Maurizio C. Capogrossi, Luigi Marzio Biasucci, Filippo Crea

Research output: Contribution to journalArticle

Abstract

To compare the anti-inflammatory and endothelial progenitor cell mobilizing effects of ramipril and telmisartan in patients presenting with acute coronary syndrome (ACS), 42 patients with ACS were randomized after successful percutaneous coronary intervention to ramipril 5 mg/day (22 patients) or telmisartan 80 mg/day (20 patients). Peripheral blood samples were drawn at baseline and at 20 days to measure high-sensitivity C-reactive protein and to assess 4 populations of progenitor cells by flow cytometry, namely CD34+/KDR+, CD34+/CD133+, CD34+/CD133+/CD45-, and CD34+/KDR+/CD45- cells. High-sensitivity C-reactive protein levels, similar in the 2 groups at baseline, were significantly more decreased by telmisartan than by ramipril at follow up (p = 0.013 for time-by-drug interaction). The main effect for time was also significant (p +/KDR+ and CD34+/CD133+ cells were similar at baseline and did not change over time (p = 0.2 and p = 0.1, respectively). In contrast, for CD34+/KDR+/CD45- and CD34+/CD133+/CD45- cells, a significant increase with time was seen (p = 0.02 and p = 0.002, respectively) and no differential effect of either drug was seen. In conclusion, telmisartan shows a more potent anti-inflammatory effect than ramipril after an ACS. The 2 drugs do not show a differential effect on endothelial progenitor cell mobilization.

Original languageEnglish
Pages (from-to)1500-1505
Number of pages6
JournalThe American Journal of Cardiology
Volume103
Issue number11
DOIs
Publication statusPublished - Jun 1 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Porto, I., Di Vito, L., De Maria, G. L., Dato, I., Tritarelli, A., Leone, A. M., Niccoli, G., Capogrossi, M. C., Biasucci, L. M., & Crea, F. (2009). Comparison of the Effects of Ramipril Versus Telmisartan on High-Sensitivity C-Reactive Protein and Endothelial Progenitor Cells After Acute Coronary Syndrome. The American Journal of Cardiology, 103(11), 1500-1505. https://doi.org/10.1016/j.amjcard.2009.01.370