Abstract
Aim of this study was to compare the effect of valsartan and felodipine on blood pressure (BP), plasma leptin (L), insulin sensitivity and plasma norepinephrine (NE) in obese hypertensive patients. Ninty-six obese patients (body mass index [BMI] ≥ 30 kg/m2) with mild to moderate essential hypertension (diastolic blood pressure [DBP] >90 and 90 mmHg). At the end of the placebo period and of active treatment period, BP and BMI were evaluated and a venous sample was drawn at the same hour in the morning to evaluate plasma L and NE. Insulin resistance index (HOMA-IR) was calculated. No dietary advice was prescribed. Both valsartan and felodipine significantly decreased BP values (-19.3/15 mmHg and - 18.9/13.6 mmHg, respectively p2, -4.7%, p
Original language | English |
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Pages (from-to) | 209-214 |
Number of pages | 6 |
Journal | Hypertension Research |
Volume | 28 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2005 |
Keywords
- Hypertension
- Insulin sensitivity
- Leptin
- Obesity
- Valsartan
ASJC Scopus subject areas
- Internal Medicine