Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients

Roberto Fogari; Giuseppe Derosa; Annalisa Zoppi; Andrea Rinaldi; Pierangelo Lazzari; Elena Fogari; Amedeo Mugellini; Paola Preti

doi:10.1291/hypres.28.209

Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients

Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Andrea Rinaldi, Pierangelo Lazzari, Elena Fogari, Amedeo Mugellini, Paola Preti

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Aim of this study was to compare the effect of valsartan and felodipine on blood pressure (BP), plasma leptin (L), insulin sensitivity and plasma norepinephrine (NE) in obese hypertensive patients. Ninty-six obese patients (body mass index [BMI] ≥ 30 kg/m²) with mild to moderate essential hypertension (diastolic blood pressure [DBP] >90 and 90 mmHg). At the end of the placebo period and of active treatment period, BP and BMI were evaluated and a venous sample was drawn at the same hour in the morning to evaluate plasma L and NE. Insulin resistance index (HOMA-IR) was calculated. No dietary advice was prescribed. Both valsartan and felodipine significantly decreased BP values (-19.3/15 mmHg and - 18.9/13.6 mmHg, respectively p2, -4.7%, p

Original language	English
Pages (from-to)	209-214
Number of pages	6
Journal	Hypertension Research
Volume	28
Issue number	3
DOIs	https://doi.org/10.1291/hypres.28.209
Publication status	Published - Mar 2005

Keywords

Hypertension
Insulin sensitivity
Leptin
Obesity
Valsartan

ASJC Scopus subject areas

Internal Medicine

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10.1291/hypres.28.209

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abstract = "Aim of this study was to compare the effect of valsartan and felodipine on blood pressure (BP), plasma leptin (L), insulin sensitivity and plasma norepinephrine (NE) in obese hypertensive patients. Ninty-six obese patients (body mass index [BMI] ≥ 30 kg/m2) with mild to moderate essential hypertension (diastolic blood pressure [DBP] >90 and 90 mmHg). At the end of the placebo period and of active treatment period, BP and BMI were evaluated and a venous sample was drawn at the same hour in the morning to evaluate plasma L and NE. Insulin resistance index (HOMA-IR) was calculated. No dietary advice was prescribed. Both valsartan and felodipine significantly decreased BP values (-19.3/15 mmHg and - 18.9/13.6 mmHg, respectively p2, -4.7%, p",

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AU - Derosa, Giuseppe

AU - Zoppi, Annalisa

AU - Rinaldi, Andrea

AU - Lazzari, Pierangelo

AU - Fogari, Elena

AU - Mugellini, Amedeo

AU - Preti, Paola

PY - 2005/3

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KW - Insulin sensitivity

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Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients

Abstract

Keywords

ASJC Scopus subject areas

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