Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients

Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Andrea Rinaldi, Pierangelo Lazzari, Elena Fogari, Amedeo Mugellini, Paola Preti

Research output: Contribution to journalArticlepeer-review

Abstract

Aim of this study was to compare the effect of valsartan and felodipine on blood pressure (BP), plasma leptin (L), insulin sensitivity and plasma norepinephrine (NE) in obese hypertensive patients. Ninty-six obese patients (body mass index [BMI] ≥ 30 kg/m2) with mild to moderate essential hypertension (diastolic blood pressure [DBP] >90 and 90 mmHg). At the end of the placebo period and of active treatment period, BP and BMI were evaluated and a venous sample was drawn at the same hour in the morning to evaluate plasma L and NE. Insulin resistance index (HOMA-IR) was calculated. No dietary advice was prescribed. Both valsartan and felodipine significantly decreased BP values (-19.3/15 mmHg and - 18.9/13.6 mmHg, respectively p2, -4.7%, p

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalHypertension Research
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Hypertension
  • Insulin sensitivity
  • Leptin
  • Obesity
  • Valsartan

ASJC Scopus subject areas

  • Internal Medicine

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