Comparison of the frequency of atopic diseases in children with severe and partial IgA deficiency

A. Plebani, V. Monafo, A. G. Ugazio, C. Monti, M. A. Avanzini, P. Massimi, G. R. Burgio

Research output: Contribution to journalArticlepeer-review

Abstract

Similar frequencies of atopic diseases and of elevated total serum IgE levels were observed in 40 children with serum IgA levels below 5 mg/dl and absence of salivary IgA (severeselective IgA deficiency, SIgAD) and in 40 children with serum IgA levels above 5 mg/dl but below -2 SD of age-normal mean values and presence of salivary IgA (partial SIgAD). These findings suggest that the absence of secretory IgA, which has been postulated to playa protective role by excluding allergens at the mucosal level, does not appear to play a crucial role in the pathogenesis of atopic diseases.

Original languageEnglish
Pages (from-to)485-486
Number of pages2
JournalInternational Archives of Allergy and Immunology
Volume82
Issue number3-4
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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