Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer

Elena Laura Mazzoldi, Anna Pastò, Giorgia Pilotto, Sonia Minuzzo, Ilaria Piga, Pietro Palumbo, Massimo Carella, Simona Frezzini, Maria Ornella Nicoletto, Alberto Amadori, Stefano Indraccolo

Research output: Contribution to journalReview articlepeer-review

Abstract

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.

Original languageEnglish
Article number368
Pages (from-to)1-10
Number of pages10
JournalJournal of Clinical Medicine
Volume9
Issue number2
DOIs
Publication statusPublished - Jan 29 2020

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