Comparison of the plasma levels of fenfluramine in rats after a toxic dose and in man after a maximal therapeutic dose

S. Garattini, S. Caccia

Research output: Contribution to journalArticle

Abstract

Plasma and brain stem levels of fenfluramine and norfenfluramine enantiomers were measured in the rat after a toxic dose of racemic fenfluramine (26.1 mg/kg i.p.) and in plasma of volunteers after a single maximal therapeutic dose (60 mg). The ratio between the peak levels reached in the rat and in man was high (35 for racemic fenfluramine). The fraction not bound to plasma protein was about 5 times larger in the rat than in man. The possibility that the supposed toxic effect of fenfluramine may have relevance at the doses given in therapy is discussed.

Original languageEnglish
Pages (from-to)285-290
Number of pages6
JournalToxicology Letters
Volume3
Issue number5
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Toxicology

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