Comparison of the safety and efficacy of delapril with enalapril in patients with congestive heart failure

Franco Rengo, Domenico Acanfora, Giuseppe Furgi, Antimo Papa, Antonio Nicolino, Costantino Picone, Dino Franco Vitale, Carlo Rengo

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate safety and efficacy of delapril versus enalapril in patients with congestive heart failure (CHF), New York Heart Association (NYHA) class II and III, 198 patients were enrolled in a study in 13 centers involving a double-blind parallel group design. After completing a 2-week run-in period on placebo, patients were randomized to receive delapril 7.5 mg twice daily or enalapril 2.5 mg twice daily for 2 weeks. The dose was then doubled for the remaining 6 weeks. In this phase, 1 patient in each group experienced orthostatic hypotension; the dose was then reduced to the initial dose for study completion. A total of 195 patients received active treatment (96 delapril, 99 enalapril). After 8 weeks' treatment, bicycle ergometry demonstrated a significant increase in exercise duration (p

Original languageEnglish
JournalThe American Journal of Cardiology
Volume75
Issue number16 SUPPL. 1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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