Comparison of three novel biphasic scaffolds for one-stage treatment of osteochondral defects in a sheep model

Francesca Gervaso, L Mangiavini, A. Giancamillo, F. Boschetti, D Izzo, D. Zani, Mauro Di Giancamillo, I Tessaro, M. Domenicucci, Francesca Scalera, Cinzia Domeneghini, A M Crovace, A. Sannino, G M Peretti

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Abstract

In the last years, several tissue engineering techniques have been applied to develop different kinds of osteochondral substitutes to overcome the scarce reparative properties of this tissue. The aim of this study was to generate and compare three biphasic scaffolds in an osteochondral lesion in a large-animal model. A critical osteochondral defect was generated in the medial femoral condyle of 18 skeletally mature sheep. Three defects were left untreated, the remaining lesions were divided into three groups: 5 lesions were treated with a biphasic scaffold made of collagen type I and small cylinders of Magnesium Hydroxyapatite; 5 lesions were treated with a biphasic substituted formed by collagen type I and Wollastonite, 5 lesions were treated with a scaffold made of collagen type I and small cylinders of Wollastonite/Hydroxyapatite. Animals were sacrificed after 3 months and samples were analyzed by CT and MRI, macroscopic evaluation and histology. Our study demonstrated that one of these novel biphasic scaffolds possesses the potential for being applied for one-stage procedures for osteochondral defects.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalJournal of Biological Regulators and Homeostatic Agents
Volume30
Issue number4 Suppl 1
Publication statusPublished - Dec 23 2016

Keywords

  • Journal Article

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    Gervaso, F., Mangiavini, L., Giancamillo, A., Boschetti, F., Izzo, D., Zani, D., Di Giancamillo, M., Tessaro, I., Domenicucci, M., Scalera, F., Domeneghini, C., Crovace, A. M., Sannino, A., & Peretti, G. M. (2016). Comparison of three novel biphasic scaffolds for one-stage treatment of osteochondral defects in a sheep model. Journal of Biological Regulators and Homeostatic Agents, 30(4 Suppl 1), 24-31.