Comparison of transesophageal echocardiographic analysis and circulating biomarker expression profile in calcific aortic valve disease

Rachana Sainger, Juan B. Grau, Emanuela Branchetti, Paolo Poggio, Eric Lai, Erblina Koka, William J. Vernick, Robert C. Gorman, Joseph E. Bavaria, Giovanni Ferrari

Research output: Contribution to journalArticle

Abstract

Background and aim of the study: Aortic valve sclerosis (AVSc), the early asymptomatic stage of calcific aortic valve disease (CAVD), is characterized by a progressive thickening of the aortic cusps without obstruction of the left ventricular outflow. In spite of its high prevalence, there are no molecular markers to characterize the early stages of CAVD before it progresses to a severe, symptomatic stage of aortic valve stenosis (AVS). The study aim was to identify any correlation between circulating biomarkers and transesophageal echocardiography (TEE) evaluation. Methods: A total of 330 patients with various degrees of CAVD was enrolled into the study. Blood was collected from each patient prior to surgery, and analyzed using ELISA kits following the manufacturers' instructions. Results: Significantly higher plasma osteopontin (OPN) levels were observed in AVSc patients (72.7 ± 1.8 ng/ml; p

Original languageEnglish
Pages (from-to)156-165
Number of pages10
JournalJournal of Heart Valve Disease
Volume22
Issue number2
Publication statusPublished - Mar 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Sainger, R., Grau, J. B., Branchetti, E., Poggio, P., Lai, E., Koka, E., Vernick, W. J., Gorman, R. C., Bavaria, J. E., & Ferrari, G. (2013). Comparison of transesophageal echocardiographic analysis and circulating biomarker expression profile in calcific aortic valve disease. Journal of Heart Valve Disease, 22(2), 156-165.