Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease

G. M C Rosano, Giuseppe Marazzi, Roberto Patrizi, Elena Cerquetani, Cristiana Vitale, Maurizio Volterrani, Massimo Fini, Giuseppe Mercuro

Research output: Contribution to journalArticlepeer-review

Abstract

A large proportion of patients who have erectile dysfunction also have coronary artery disease (CAD). In these patients, nitrate therapy is a contraindication to the use of sildenafil. To assess whether the metabolic anti-ischemic agent, trimetazidine, is effective in controlling episodes of myocardial ischemia during sexual activity in patients who have CAD and use long-term nitrate therapy, we studied 38 men (57 ± 6 years of age) who had proved CAD. Patients underwent 24-hour ambulatory electrocardiographic monitoring at baseline, after 1 week of oral nitrate therapy (20 mg 3 times a day), and after 1 week of trimetazidine (20 mg 3 times a day). Patients were asked to engage in

Original languageEnglish
Pages (from-to)327-331
Number of pages5
JournalThe American Journal of Cardiology
Volume95
Issue number3
DOIs
Publication statusPublished - Feb 1 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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