TY - JOUR
T1 - Comparison of trimetazidine plus sildenafil to chronic nitrates in the control of myocardial ischemia during sexual activity in patients with coronary artery disease
AU - Rosano, G. M C
AU - Marazzi, Giuseppe
AU - Patrizi, Roberto
AU - Cerquetani, Elena
AU - Vitale, Cristiana
AU - Volterrani, Maurizio
AU - Fini, Massimo
AU - Mercuro, Giuseppe
PY - 2005/2/1
Y1 - 2005/2/1
N2 - A large proportion of patients who have erectile dysfunction also have coronary artery disease (CAD). In these patients, nitrate therapy is a contraindication to the use of sildenafil. To assess whether the metabolic anti-ischemic agent, trimetazidine, is effective in controlling episodes of myocardial ischemia during sexual activity in patients who have CAD and use long-term nitrate therapy, we studied 38 men (57 ± 6 years of age) who had proved CAD. Patients underwent 24-hour ambulatory electrocardiographic monitoring at baseline, after 1 week of oral nitrate therapy (20 mg 3 times a day), and after 1 week of trimetazidine (20 mg 3 times a day). Patients were asked to engage in
AB - A large proportion of patients who have erectile dysfunction also have coronary artery disease (CAD). In these patients, nitrate therapy is a contraindication to the use of sildenafil. To assess whether the metabolic anti-ischemic agent, trimetazidine, is effective in controlling episodes of myocardial ischemia during sexual activity in patients who have CAD and use long-term nitrate therapy, we studied 38 men (57 ± 6 years of age) who had proved CAD. Patients underwent 24-hour ambulatory electrocardiographic monitoring at baseline, after 1 week of oral nitrate therapy (20 mg 3 times a day), and after 1 week of trimetazidine (20 mg 3 times a day). Patients were asked to engage in
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U2 - 10.1016/j.amjcard.2004.09.028
DO - 10.1016/j.amjcard.2004.09.028
M3 - Article
C2 - 15670539
AN - SCOPUS:12844285144
VL - 95
SP - 327
EP - 331
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 3
ER -