Comparison of two different conditioning regimens before autologous transplantation for children with high-risk neuroblastoma

Maria Antonietta De Ioris, Benedetta Contoli, Alessandro Jenkner, Maria Debora De Pasquale, Annalisa Serra, Luigi De Sio, Rosanna Pessolano, Maria Carmen Garganese, Alessandro Crocoli, Teresa Corneli, Renata Boldrini, Aurora Castellano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although high-dose chemotherapy (HDC) represents the standard of treatment for high-risk neuroblastoma (NBL), the most effective conditioning regimen still remains to be identified. Patients and Methods: Forty-one high-risk NBL entered into local protocol based on induction chemotherapy, surgery and HDC with either etoposide/ thiotepa/cyclophophamide (ETC) or i.v. busulfan and L-PAM (Bu/L-PAM). Results: Thirty-seven patients underwent HDC; 29 with ETC and 8 with Bu/L-PAM. No toxic deaths were recorded. The 5-year progression-free survival (PFS) of patients given ETC was 21% (95% confidence interval CI (9- 36%), while PFS for patients given Bu/L-PAM was 88% (95% CI=39-98%) (p

Original languageEnglish
Pages (from-to)5427-5434
Number of pages8
JournalAnticancer Research
Volume32
Issue number12
Publication statusPublished - Dec 2012

Keywords

  • Busulfan
  • Conditioning regimen
  • Neuroblastoma
  • Thiotepa

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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