Comparison of two dose regimens of zidovudine in an open, randomized, multicentre study for severe HIV-related thrombocytopenia

Giuseppe Landonio, Paola Cinque, Annamaria Nosari, Sergio Gafa, Francesco Rizzo, Massimo Coen, Umberto Tirelli, Liliana Caggese, Umberto Di Luzio Paparatti, Adriano Lazzarin

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To compare the effect of two dose regimens of zidovudine in the treatment of severe HIV-related thrombocytopenia (TP). Design: Eighty-four patients with severe HIV-related TP and platelet counts <50 × 109/l were enrolled in an open study at six centres. Patients were randomized into two groups to receive zidovudine (group A, 500 mg per day; group B, 1000 mg per day) for 6 months. Methods: Platelet counts were determined monthly and patients categorized as complete responders (CR; platelets > 100 × 109/l), partial responders (PR; platelets > 50 to <100 × 109/l), or failures (F; platelets to <50 × 109/l). CD4+ and CD8+ lymphocytes, HIV antigenaemia, β2-microglobulin, white blood cells, mean cell volume and haemoglobin were also determined. Results: Seventy-one patients (35 and 36 in groups A and B, respectively) completed the study; 11.4% of group A patients were CR and 45.7% PR; 38.9% of group B were CR and 33.3% PR. Increase in mean platelet counts was dose-related, more rapid in the higher dose group and remained significantly higher after 6 months of treatment (56.4 × 109/l in group A versus 98.2 × 109/l in group B; P <0.01). Conclusions: The results confirm the efficacy of zidovudine in the treatment of severe HIV-related TP. The average for CR and PR in the two groups was 64.8%; the higher dose of zidovudine was more effective at increasing platelet counts.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalAIDS (London, England)
Volume7
Issue number2
Publication statusPublished - Feb 1993

Keywords

  • Dose
  • HIV-related thrombocytopenia
  • Therapy
  • Zidovudine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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