Comparison of two enteric coated microsphere preparations in the treatment of pancreatic exocrine insufficiency caused by cystic fibrosis

B. Santini, M. Antonelli, A. Battistini, S. Bertasi, M. Collura, I. Esposito, L. Di Febbraro, R. Ferrari, L. Ferrero, L. Iapichino, V. Lucidi, A. Manca, C. L. Pisconti, G. Pisi, V. Raia, L. Romano, P. Rosati, I. Grazioli, G. Melzi

Research output: Contribution to journalArticle

Abstract

Background. Pancreatic exocrine insufficiency is a common condition in patients with cystic fibrosis. Large amounts of pancreatic enzyme supplements are required to reduce malabsorption but patient compliance is not always optimal. Aims. To compare patients' preference and the efficacy of two enteric coated microsphere preparations in patients with cystic fibrosis. Patients. Patients with pancreatic exocrine insufficiency due to cystic fibrosis. Methods. Patients were assigned to the crossover treatment with Creon® or Pancrease® for 1 week and then to the alternative treatment. Patients had to follow a fixed diet [at least 2 g fat/kg] and had to assume 1000 units lipase/g fat. The evaluation parameters were: patients' preference, acceptance of therapy, stool fat excretion, stool weight, gastrointestinal symptoms, and tolerance. Results and conclusions. Of the 33/60 patients who expressed a preference for one of the two treatments, 30 preferred Creon® while only 3 patients preferred Pancrease® [p

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalDigestive and Liver Disease
Volume32
Issue number5
Publication statusPublished - 2000

Keywords

  • Cystic fibrosis
  • Malabsorption
  • Pancreatic exocrine insufficiency
  • Pancreatic extracts

ASJC Scopus subject areas

  • Gastroenterology

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    Santini, B., Antonelli, M., Battistini, A., Bertasi, S., Collura, M., Esposito, I., Di Febbraro, L., Ferrari, R., Ferrero, L., Iapichino, L., Lucidi, V., Manca, A., Pisconti, C. L., Pisi, G., Raia, V., Romano, L., Rosati, P., Grazioli, I., & Melzi, G. (2000). Comparison of two enteric coated microsphere preparations in the treatment of pancreatic exocrine insufficiency caused by cystic fibrosis. Digestive and Liver Disease, 32(5), 406-411.