Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours: A randomized controlled study

S. Palomba, E. Zupi, T. Russo, A. Falbo, S. Del Negro, F. Manguso, D. Marconi, A. Tolino, F. Zullo

Research output: Contribution to journalArticle

Abstract

Background: During the childbearing years, the standard fertility-sparing treatment for bilateral borderline ovarian tumours (BOTs) is the unilateral oophorectomy plus controlateral cystectomy. The aim of the present study was to compare the effects of two laparoscopic fertility-sparing surgical procedures for the treatment of bilateral BOTs on recurrence and fertility in young women who desire to conceive as soon as possible. Methods: Thirty-two women affected by bilateral early-stage BOTs who desired to conceive were randomized to receive bilateral cystectomy (experimental group, n = 15) or oophorectomy plus controlateral cystectomy (control group, n = 17). At the first recurrence after childbearing completion, each patient was treated with non-conservative standard treatment. Recurrences and reproductive events were recorded. Results: After a follow-up period of 81 months (19 inter-quartile; 60-96 range), the cumulative pregnancy rate (CPR) (14/15 versus 9/17; P = 0.003) and the cumulative probability of first pregnancy (P = 0.011) were significantly higher in the experimental than in control group. No significant (P = 0.358) difference between groups was detected in cumulative probability of first recurrence. Conclusions: The laparoscopic bilateral cystectomy followed by non-conservative treatment performed at the first recurrence after the childbearing completion is an effective surgical strategy for patients with bilateral early-stage BOTs who desire to conceive as soon as possible.

Original languageEnglish
Pages (from-to)578-585
Number of pages8
JournalHuman Reproduction
Volume22
Issue number2
DOIs
Publication statusPublished - Feb 2007

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Cystectomy
Fertility
Recurrence
Ovariectomy
Neoplasms
Control Groups
Pregnancy Rate
Therapeutics
Pregnancy

Keywords

  • Borderline ovarian tumour
  • Cystectomy
  • Fertility
  • Recurrence
  • Surgery

ASJC Scopus subject areas

  • Physiology
  • Developmental Biology
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours : A randomized controlled study. / Palomba, S.; Zupi, E.; Russo, T.; Falbo, A.; Del Negro, S.; Manguso, F.; Marconi, D.; Tolino, A.; Zullo, F.

In: Human Reproduction, Vol. 22, No. 2, 02.2007, p. 578-585.

Research output: Contribution to journalArticle

Palomba, S, Zupi, E, Russo, T, Falbo, A, Del Negro, S, Manguso, F, Marconi, D, Tolino, A & Zullo, F 2007, 'Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours: A randomized controlled study', Human Reproduction, vol. 22, no. 2, pp. 578-585. https://doi.org/10.1093/humrep/del381
Palomba, S. ; Zupi, E. ; Russo, T. ; Falbo, A. ; Del Negro, S. ; Manguso, F. ; Marconi, D. ; Tolino, A. ; Zullo, F. / Comparison of two fertility-sparing approaches for bilateral borderline ovarian tumours : A randomized controlled study. In: Human Reproduction. 2007 ; Vol. 22, No. 2. pp. 578-585.
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