Comparison of two medications in central nervous system toxoplasmosis in patients with AIDS

A. Antinori, A. Ammassari, G. Maiuro, G. Camilli, F. Damiano, G. Federico, E. Pizzigallo, E. Tamburrini

Research output: Contribution to journalArticlepeer-review

Abstract

We retrospectively examined 39 patients with AIDS and central nrvous system toxoplasmosis in order to determine the efficacy and safety of two combinations: pyrimethamine-sulfadiazine and pyrimethamine-clindamycin. The results showed a response rate of 79% for the sulfadiazine association and a high failure rate in the clindamycin group. Side effects with sulfadiazine were slightly more frequent, but with desensitization protocols discontinuation was kept down. The combination of pyrimethamine and sulfadiazine, associated, when necessary, with desensitization schedules, was confirmed to be first choice therapy for cerebral toxoplasmosis in AIDS patients. The role of alternative regimens needs further evaluation.

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalItalian Journal of Neurological Sciences
Volume13
Issue number6
DOIs
Publication statusPublished - Sep 1992

Keywords

  • pyrimethamine
  • sulfadiazine
  • Toxoplasmosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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