Comparison of urethane-induced sister-chromatid exchanges in various murine strains, and the effect of enzyme inducers

Tommaso A. Dragani, Gabriella Sozzi, Giuseppe Della Porta

Research output: Contribution to journalArticlepeer-review

Abstract

The induction of sister-chromatid exchanges (SCEs) by urethane, 150 and 300 mg/kg administered i.p., was examined in bone-marrow cells of AKR, BALB/c, C3Hf, C57BL/6J and DBA/2 male mice. In all strains, the base-line level of SCE/cell was similar, ranging from 4.3 to 8.7, and the response increased with the dose of urethane. DBA/2 mice were the most susceptible to urethane at both dose levels, with 30.6 SCE/cell after treatment with 300 mg/kg, whereas the response of the other strains was from 17.4 to 21.5 SCE/cell at the same urethane dose. Pre-treatment of C57BL/6J and DBA/2 mice with phenobarbital decreased the SCE frequencies induced by urethane, 300 mg/kg, to 70%, whereas a prior administration of β-naphthoflavone reduced SCE levels in C57BL/6J but not in DBA/2 mice.

Original languageEnglish
Pages (from-to)233-239
Number of pages7
JournalMutation Research Letters
Volume121
Issue number3-4
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

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