Comparison of urethane-induced sister-chromatid exchanges in various murine strains, and the effect of enzyme inducers

Tommaso A. Dragani; Gabriella Sozzi; Giuseppe Della Porta

doi:10.1016/0165-7992(83)90208-7

Comparison of urethane-induced sister-chromatid exchanges in various murine strains, and the effect of enzyme inducers

Tommaso A. Dragani, Gabriella Sozzi, Giuseppe Della Porta

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The induction of sister-chromatid exchanges (SCEs) by urethane, 150 and 300 mg/kg administered i.p., was examined in bone-marrow cells of AKR, BALB/c, C3Hf, C57BL/6J and DBA/2 male mice. In all strains, the base-line level of SCE/cell was similar, ranging from 4.3 to 8.7, and the response increased with the dose of urethane. DBA/2 mice were the most susceptible to urethane at both dose levels, with 30.6 SCE/cell after treatment with 300 mg/kg, whereas the response of the other strains was from 17.4 to 21.5 SCE/cell at the same urethane dose. Pre-treatment of C57BL/6J and DBA/2 mice with phenobarbital decreased the SCE frequencies induced by urethane, 300 mg/kg, to 70%, whereas a prior administration of β-naphthoflavone reduced SCE levels in C57BL/6J but not in DBA/2 mice.

Original language	English
Pages (from-to)	233-239
Number of pages	7
Journal	Mutation Research Letters
Volume	121
Issue number	3-4
DOIs	https://doi.org/10.1016/0165-7992(83)90208-7
Publication status	Published - 1983

ASJC Scopus subject areas

Genetics
Toxicology
Medicine(all)

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@article{f8e5935185c24792a56c6761593c1675,

title = "Comparison of urethane-induced sister-chromatid exchanges in various murine strains, and the effect of enzyme inducers",

abstract = "The induction of sister-chromatid exchanges (SCEs) by urethane, 150 and 300 mg/kg administered i.p., was examined in bone-marrow cells of AKR, BALB/c, C3Hf, C57BL/6J and DBA/2 male mice. In all strains, the base-line level of SCE/cell was similar, ranging from 4.3 to 8.7, and the response increased with the dose of urethane. DBA/2 mice were the most susceptible to urethane at both dose levels, with 30.6 SCE/cell after treatment with 300 mg/kg, whereas the response of the other strains was from 17.4 to 21.5 SCE/cell at the same urethane dose. Pre-treatment of C57BL/6J and DBA/2 mice with phenobarbital decreased the SCE frequencies induced by urethane, 300 mg/kg, to 70%, whereas a prior administration of β-naphthoflavone reduced SCE levels in C57BL/6J but not in DBA/2 mice.",

author = "Dragani, {Tommaso A.} and Gabriella Sozzi and {Della Porta}, Giuseppe",

year = "1983",

doi = "10.1016/0165-7992(83)90208-7",

language = "English",

volume = "121",

pages = "233--239",

journal = "Mutation Research Letters",

issn = "0165-7992",

publisher = "Elsevier BV",

number = "3-4",

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T1 - Comparison of urethane-induced sister-chromatid exchanges in various murine strains, and the effect of enzyme inducers

AU - Dragani, Tommaso A.

AU - Sozzi, Gabriella

AU - Della Porta, Giuseppe

PY - 1983

Y1 - 1983

N2 - The induction of sister-chromatid exchanges (SCEs) by urethane, 150 and 300 mg/kg administered i.p., was examined in bone-marrow cells of AKR, BALB/c, C3Hf, C57BL/6J and DBA/2 male mice. In all strains, the base-line level of SCE/cell was similar, ranging from 4.3 to 8.7, and the response increased with the dose of urethane. DBA/2 mice were the most susceptible to urethane at both dose levels, with 30.6 SCE/cell after treatment with 300 mg/kg, whereas the response of the other strains was from 17.4 to 21.5 SCE/cell at the same urethane dose. Pre-treatment of C57BL/6J and DBA/2 mice with phenobarbital decreased the SCE frequencies induced by urethane, 300 mg/kg, to 70%, whereas a prior administration of β-naphthoflavone reduced SCE levels in C57BL/6J but not in DBA/2 mice.

AB - The induction of sister-chromatid exchanges (SCEs) by urethane, 150 and 300 mg/kg administered i.p., was examined in bone-marrow cells of AKR, BALB/c, C3Hf, C57BL/6J and DBA/2 male mice. In all strains, the base-line level of SCE/cell was similar, ranging from 4.3 to 8.7, and the response increased with the dose of urethane. DBA/2 mice were the most susceptible to urethane at both dose levels, with 30.6 SCE/cell after treatment with 300 mg/kg, whereas the response of the other strains was from 17.4 to 21.5 SCE/cell at the same urethane dose. Pre-treatment of C57BL/6J and DBA/2 mice with phenobarbital decreased the SCE frequencies induced by urethane, 300 mg/kg, to 70%, whereas a prior administration of β-naphthoflavone reduced SCE levels in C57BL/6J but not in DBA/2 mice.

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