Comparison of various techniques used to estimate spontaneous baroreflex sensitivity (the EuroBaVar study)

Dominique Laude, Jean Luc Elghozi, Arlette Girard, Elisabeth Bellard, Malika Bouhaddi, Paolo Castiglioni, Catherine Cerutti, Andrei Cividjian, Marco Di Rienzo, Jacques Olivier Fortrat, Ben Janssen, John M. Karemaker, Georges Lefthériotis, Gianfranco Parati, Pontus B. Persson, Alberto Porta, Luc Quintin, Jacques Regnard, Heinz Rüdiger, Harald M. Stauss

Research output: Contribution to journalArticlepeer-review


This study compared spontaneous baroreflex sensitivity (BRS) estimates obtained from an identical set of data by 11 European centers using different methods and procedures. Noninvasive blood pressure (BP) and ECG recordings were obtained in 21 subjects, including 2 subjects with established baroreflex failure. Twenty-one estimates of BRS were obtained by methods including the two main techniques of BRS estimates, i.e., the spectral analysis (11 procedures) and the sequence method (7 procedures) but also one trigonometric regressive spectral analysis method (TRS), one exogenous model with autoregressive input method (X-AR), and one Z method. With subjects in a supine position, BRS estimates obtained with calculations of α-coefficient or gain of the transfer function in both the low-frequency band or high-frequency band, TRS, and sequence methods gave strongly related results. Conversely, weighted gain, X-AR, and Z exhibited lower agreement with all the other techniques. In addition, the use of mean BP instead of systolic BP in the sequence method decreased the relationships with the other estimates. Some procedures were unable to provide results when BRS estimates were expected to be very low in data sets (in patients with established baroreflex failure). The failure to provide BRS values was due to setting of algorithmic parameters too strictly. The discrepancies between procedures show that the choice of parameters and data handling should be considered before BRS estimation. These data are available on the web site ( to allow the comparison of new techniques with this set of results.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number1 55-1
Publication statusPublished - Jan 2004


  • Autonomic nervous system
  • Baroreceptor reflex
  • Sequence technique
  • Spectral analysis

ASJC Scopus subject areas

  • Physiology


Dive into the research topics of 'Comparison of various techniques used to estimate spontaneous baroreflex sensitivity (the EuroBaVar study)'. Together they form a unique fingerprint.

Cite this