Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension

Monica Varano, Pierluigi Iacono, Massimiliano M. Tedeschi, Claudio Letizia, Mario Curione, Claudio Savoriti, Erika Baiocco, Laura Zinnamosca, Cristiano Marinelli, Barbara Boccassini, Mariacristina Parravano

Research output: Contribution to journalArticle

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Abstract

Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse wave velocity (PWV) were assessed using a TensioClinic arteriograph system. Retinal microcirculation was imaged by a Retinal Vessel Analyzer (RVA) and a non-midriatic camera (Topcon-TRC-NV2000). IMEDOS software analyzed the retinal artery diameter (RAD), retinal vein diameters (RVD) and arteriole-To-venule ratio (AVR) of the vessels coming off the optic disc. Thirty, 39 and 35 patients were included in the PA, EH and control group, respectively. The PA group showed higher PWV values compared only with the control group. The mean brachial and aortic AIx values did not show significant difference between groups. In the PA group, the mean RVD and AVR values were significantly lower than in the EH and control groups, whereas the parameters did not differ between the EH and control groups. In conclusion, AVR appears significantly modified in the PA group compared with the EH group and could represent an early and more reliable indicator of microvascular remodeling.

Original languageEnglish
Article number2666
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Jun 1 2017

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Hyperaldosteronism
Venules
Hypertension
Arterioles
Retinal Vein
Control Groups
Pulse Wave Analysis
Retinal Artery
Retinal Vessels
Vascular Stiffness
Optic Disk
Microcirculation
Observational Studies
Case-Control Studies
Healthy Volunteers
Arm
Software
Essential Hypertension

ASJC Scopus subject areas

  • General

Cite this

Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension. / Varano, Monica; Iacono, Pierluigi; Tedeschi, Massimiliano M.; Letizia, Claudio; Curione, Mario; Savoriti, Claudio; Baiocco, Erika; Zinnamosca, Laura; Marinelli, Cristiano; Boccassini, Barbara; Parravano, Mariacristina.

In: Scientific Reports, Vol. 7, No. 1, 2666, 01.06.2017.

Research output: Contribution to journalArticle

Varano, Monica ; Iacono, Pierluigi ; Tedeschi, Massimiliano M. ; Letizia, Claudio ; Curione, Mario ; Savoriti, Claudio ; Baiocco, Erika ; Zinnamosca, Laura ; Marinelli, Cristiano ; Boccassini, Barbara ; Parravano, Mariacristina. / Comparisons of microvascular and macrovascular changes in aldosteronism-related hypertension and essential hypertension. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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