Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes

Cesare Piazza, Alberto Grammatica, Nausica Montalto, Alberto Paderno, Francesca Del Bon, Piero Nicolai

Research output: Contribution to journalArticle

Abstract

Background: Oral tongue/floor of mouth squamous cell carcinoma (OTFMSCC) with a depth of invasion (DOI) > 10 mm involves extrinsic muscles and lingual neurovascular/lymphatic bundles. “Compartmental” hemiglossopelvectomy (CHGP) was developed to improve loco-regional control by “en bloc” removal of tumor and its pathways of spread. Methods: We conducted a retrospective observational study on 45 CHGPs performed at a single institution for OTFMSCC with a DOI > 10 mm at CT/MR. Group A (n = 35) included naïve patients, and group B (n = 10) recurrent cancers. We evaluated 2-year overall survival (OS), disease-free survival (DFS), local control (LC), and loco-regional control (LRC). Results: Two-year OS, DFS, LC, and LRC were 80%, 91%, 100%, and 94% for group A, and 27%, 26%, 67%, and 36% for group B, respectively. Salvage surgery and positive margins were significantly associated with worse prognosis. Conclusion: CHGP is a reliable oncologic approach in primary surgery for advanced OTFMSCC. In recurrent cancers, survival remains poor.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalHead and Neck
Volume41
Issue number1
DOIs
Publication statusPublished - Jan 2019

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Keywords

  • compartmental surgery
  • floor of mouth
  • hemiglossopelvectomy
  • oral tongue
  • squamous cell carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Piazza, C., Grammatica, A., Montalto, N., Paderno, A., Del Bon, F., & Nicolai, P. (2019). Compartmental surgery for oral tongue and floor of the mouth cancer: Oncologic outcomes. Head and Neck, 41(1), 110-115. https://doi.org/10.1002/hed.25480