Compartmental tongue surgery: Long term oncologic results in the treatment of tongue cancer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4% of CTS patients (16.8% improvement on standard surgery); locoregional disease control in 83.5% (24.4% improvement) and overall survival was 70.7% (27.3% improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.

Original languageEnglish
Pages (from-to)174-179
Number of pages6
JournalOral Oncology
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Tongue Neoplasms
Tongue
Therapeutics
Squamous Cell Carcinoma
Muscles
Muscular Diseases
Informed Consent
Ligaments
Disease-Free Survival
Blood Vessels
Anesthesia
Retrospective Studies
Recurrence

Keywords

  • Compartmental surgery
  • Oncological results
  • Tongue cancer

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

@article{961282ba49bb4b95a4f8bf496a7fab9a,
title = "Compartmental tongue surgery: Long term oncologic results in the treatment of tongue cancer",
abstract = "Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4{\%} of CTS patients (16.8{\%} improvement on standard surgery); locoregional disease control in 83.5{\%} (24.4{\%} improvement) and overall survival was 70.7{\%} (27.3{\%} improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.",
keywords = "Compartmental surgery, Oncological results, Tongue cancer",
author = "Luca Calabrese and Roberto Bruschini and Gioacchino Giugliano and Angelo Ostuni and Fausto Maffini and Massaro, {Maria Angela} and Luigi Santoro and Valeria Navach and Lorenzo Preda and Daniela Alterio and Mohssen Ansarin and Fausto Chiesa",
year = "2011",
month = "3",
doi = "10.1016/j.oraloncology.2010.12.006",
language = "English",
volume = "47",
pages = "174--179",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Compartmental tongue surgery

T2 - Long term oncologic results in the treatment of tongue cancer

AU - Calabrese, Luca

AU - Bruschini, Roberto

AU - Giugliano, Gioacchino

AU - Ostuni, Angelo

AU - Maffini, Fausto

AU - Massaro, Maria Angela

AU - Santoro, Luigi

AU - Navach, Valeria

AU - Preda, Lorenzo

AU - Alterio, Daniela

AU - Ansarin, Mohssen

AU - Chiesa, Fausto

PY - 2011/3

Y1 - 2011/3

N2 - Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4% of CTS patients (16.8% improvement on standard surgery); locoregional disease control in 83.5% (24.4% improvement) and overall survival was 70.7% (27.3% improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.

AB - Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4% of CTS patients (16.8% improvement on standard surgery); locoregional disease control in 83.5% (24.4% improvement) and overall survival was 70.7% (27.3% improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.

KW - Compartmental surgery

KW - Oncological results

KW - Tongue cancer

UR - http://www.scopus.com/inward/record.url?scp=79952280013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952280013&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2010.12.006

DO - 10.1016/j.oraloncology.2010.12.006

M3 - Article

C2 - 21257337

AN - SCOPUS:79952280013

VL - 47

SP - 174

EP - 179

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 3

ER -