Abstract
Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4% of CTS patients (16.8% improvement on standard surgery); locoregional disease control in 83.5% (24.4% improvement) and overall survival was 70.7% (27.3% improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 174-179 |
| Number of pages | 6 |
| Journal | Oral Oncology |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2011 |
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Keywords
- Compartmental surgery
- Oncological results
- Tongue cancer
ASJC Scopus subject areas
- Oncology
- Oral Surgery
- Cancer Research
Cite this
Compartmental tongue surgery : Long term oncologic results in the treatment of tongue cancer. / Calabrese, Luca; Bruschini, Roberto; Giugliano, Gioacchino; Ostuni, Angelo; Maffini, Fausto; Massaro, Maria Angela; Santoro, Luigi; Navach, Valeria; Preda, Lorenzo; Alterio, Daniela; Ansarin, Mohssen; Chiesa, Fausto.
In: Oral Oncology, Vol. 47, No. 3, 03.2011, p. 174-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Compartmental tongue surgery
T2 - Long term oncologic results in the treatment of tongue cancer
AU - Calabrese, Luca
AU - Bruschini, Roberto
AU - Giugliano, Gioacchino
AU - Ostuni, Angelo
AU - Maffini, Fausto
AU - Massaro, Maria Angela
AU - Santoro, Luigi
AU - Navach, Valeria
AU - Preda, Lorenzo
AU - Alterio, Daniela
AU - Ansarin, Mohssen
AU - Chiesa, Fausto
PY - 2011/3
Y1 - 2011/3
N2 - Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4% of CTS patients (16.8% improvement on standard surgery); locoregional disease control in 83.5% (24.4% improvement) and overall survival was 70.7% (27.3% improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.
AB - Compartmental tongue surgery (CTS) is a surgical technique that removes the compartments (anatomo-functional units) containing the primary tumor, eliminating the disease and potential muscular, vascular, glandular and lymphatic pathways of spread and recurrence. Compartment boundaries are defined as each hemi-tongue bounded by the lingual septum, the stylohyoid ligament and muscle, and the mylohyoid muscle. In this non-randomized retrospective study we evaluated the oncologic efficacy of CTS in patients with squamous cell carcinoma (SCCA) of the tongue treated from 1995 to 2008. We evaluated 193 patients with primary, previously untreated cT2-4a, cN0, cN+, M0 SCCA with no contraindication to anesthesia and able to give informed consent. Fifty patients treated between October 1995 and July 1999 received standard surgery (resection margin >1 cm); 143 patients treated between July 1999 and January 2008 received CTS. Study endpoints were: 5-year local disease-free, locoregional disease-free and overall survival. After 5 years, local disease control was achieved in 88.4% of CTS patients (16.8% improvement on standard surgery); locoregional disease control in 83.5% (24.4% improvement) and overall survival was 70.7% (27.3% improvement). The markedly improved outcomes in CTS patients, compared to those treated by standard surgery, suggest CTS as an important new approach in the surgical management of tongue cancer.
KW - Compartmental surgery
KW - Oncological results
KW - Tongue cancer
UR - http://www.scopus.com/inward/record.url?scp=79952280013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952280013&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2010.12.006
DO - 10.1016/j.oraloncology.2010.12.006
M3 - Article
C2 - 21257337
AN - SCOPUS:79952280013
VL - 47
SP - 174
EP - 179
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 3
ER -