Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: Six degrees of separation

Research output: Contribution to journalArticle

Abstract

The efficacy of targeted therapies against mutationally activated kinases is typically limited by the engagement of growth-promoting cues that compensate for inhibition of the targeted kinase. Initial studies have highlighted the contribution of genomic alterations, functional characteristics, and signaling feedback loops-all intrinsic to cancer cells-in sustaining such substitute activities. New evidence now indicates that the relative expression of growth factor ligands produced by the tumor microenvironment can relay redundant survival pathways, which may broadly impair responsiveness to kinase inhibitors.

Original languageEnglish
Pages (from-to)876-880
Number of pages5
JournalCancer Discovery
Volume2
Issue number10
DOIs
Publication statusPublished - Oct 2012

ASJC Scopus subject areas

  • Oncology

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