Complement anaphylatoxins in idiopathic mixed cryoglobulinemia

A. Miadonna, E. Leggieri, A. Tedeschi, M. Cottini, F. Invernizzi, M. Froldi, C. Zanussi

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Basophil activation, observed in patients with idiopathic mixed cryoglobulinemia, has been related to the complement anaphylatoxins C4a, C3a and C5a. In the present study the plasma levels of the complement anaphylatoxins have been evaluated in 21 patients affected with idiopathic mixed cryoglobulinemia. The plasma concentration of C3a desArg was significantly higher in the patients than in the healthy controls; conversely the plasma values of C4a desArg were significantly lower. C5a desArg was not detectable in plasma from any subject. The high plasma level of C3a desArg in our patients may suggest a role for C3a anaphylatoxin in 'in vivo' basophil activation. No correlation was found between the plasma concentrations of C3a desArg or C4a desArg, the amount of cryoprecipitate and the clinical activity of the disease.

Original languageEnglish
Pages (from-to)120-125
Number of pages6
JournalInternational Archives of Allergy and Applied Immunology
Issue number2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy

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