Abstract
Gross cystic disease (GCDB) is a breast benign condition predisposing to breast cancer. Cryopreserved sera from GCDB patients, some of whom later developed a cancer (cases), were studied to identify potential risk markers. A MALDI-TOF mass spectrometry analysis found several complement C3f fragments having a significant increased abundance in cases compared to controls. After multivariate analysis, the full-length form of C3f maintained a predictive value of breast cancer risk. Higher levels of C3f in the serum of women affected by a benign condition like GCDB thus appears to be correlated to the development of breast cancer even 20. years later. Biological significance: Increased complement system activation has been found in the sera of women affected by GCDB who developed a breast cancer, even twenty or more years later. C3f may predict an increased breast cancer risk in the healthy population and in women affected by predisposing conditions.
Original language | English |
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Pages (from-to) | 44-52 |
Number of pages | 9 |
Journal | Journal of Proteomics |
Volume | 85 |
DOIs | |
Publication status | Published - Jun 24 2013 |
Keywords
- Breast cancer risk
- Complement C3f
- MALDI-TOF
- Peptidome profile
- Serum
ASJC Scopus subject areas
- Biochemistry
- Biophysics