Complement cascade in systemic lupus erythematosus: Analyses of the three activation pathways

Angela Ceribelli, Laura Andreoli, Ilaria Cavazzana, Franco Franceschini, Antonella Radice, Laura Rimoldi, Renato Alberto Sinico, Malin Carlsson, Jorgen Wieslander, Angela Tincani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages427-434
Number of pages8
Volume1173
DOIs
Publication statusPublished - Sep 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1173
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • Complement (C') cascade
  • Complement deficiency
  • Complement ELISA kit
  • Complement pathways
  • Systemic lupus erythematosus (SLE)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Ceribelli, A., Andreoli, L., Cavazzana, I., Franceschini, F., Radice, A., Rimoldi, L., Sinico, R. A., Carlsson, M., Wieslander, J., & Tincani, A. (2009). Complement cascade in systemic lupus erythematosus: Analyses of the three activation pathways. In Annals of the New York Academy of Sciences (Vol. 1173, pp. 427-434). (Annals of the New York Academy of Sciences; Vol. 1173). https://doi.org/10.1111/j.1749-6632.2009.04921.x