Unspecific binding of immunoglobulins to gastrin, somatostatin and glucagon cells of the gastrointestinal mucosa or pancreas has been found to occur through a nonantigen-antibody mechanism mediated by the C(1q)fraction of complement. The phenomenon represents an important drawback in hormone immunohistochemistry, which can be overcome by using complement deprived, highly dilute anti-hormone sera.
|Number of pages||2|
|Journal||Journal of Histochemistry and Cytochemistry|
|Publication status||Published - 1979|
ASJC Scopus subject areas
- Cell Biology