Complement-mediated binding of immunoglobulins to some endocrine cells of the pancreas and gut

R. Buffa, E. Solcia, R. Fiocca, O. Crivelli, A. Pera

Research output: Contribution to journalArticlepeer-review

Abstract

Unspecific binding of immunoglobulins to gastrin, somatostatin and glucagon cells of the gastrointestinal mucosa or pancreas has been found to occur through a nonantigen-antibody mechanism mediated by the C(1q)fraction of complement. The phenomenon represents an important drawback in hormone immunohistochemistry, which can be overcome by using complement deprived, highly dilute anti-hormone sera.

Original languageEnglish
Pages (from-to)1279-1280
Number of pages2
JournalJournal of Histochemistry and Cytochemistry
Volume27
Issue number9
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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