Complement-mediated unspecific binding of immunoglobulins to some endocrine cells

R. Buffa, O. Crivelli, R. Fiocca, P. Fontana, E. Solcia

Research output: Contribution to journalArticlepeer-review

Abstract

Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes.

Original languageEnglish
Pages (from-to)15-21
Number of pages7
JournalHistochemistry
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 1979

ASJC Scopus subject areas

  • Anatomy

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