Complement-mediated unspecific binding of immunoglobulins to some endocrine cells

R. Buffa; O. Crivelli; R. Fiocca; P. Fontana; E. Solcia

doi:10.1007/BF00508008

Complement-mediated unspecific binding of immunoglobulins to some endocrine cells

R. Buffa, O. Crivelli, R. Fiocca, P. Fontana, E. Solcia

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Abstract

Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C_1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C_1q antibodies or with complement-fixing immunocomplexes.

Original language	English
Pages (from-to)	15-21
Number of pages	7
Journal	Histochemistry
Volume	63
Issue number	1
DOIs	https://doi.org/10.1007/BF00508008
Publication status	Published - Jan 1979

ASJC Scopus subject areas

Anatomy

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author = "R. Buffa and O. Crivelli and R. Fiocca and P. Fontana and E. Solcia",

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AU - Fiocca, R.

AU - Fontana, P.

AU - Solcia, E.

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AB - Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes.

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Complement-mediated unspecific binding of immunoglobulins to some endocrine cells

Abstract

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