Abstract
Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes.
Original language | English |
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Pages (from-to) | 15-21 |
Number of pages | 7 |
Journal | Histochemistry |
Volume | 63 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1979 |
ASJC Scopus subject areas
- Anatomy