Complement receptor 1 gene polymorphisms in sarcoidosis

Michele Zorzetto, Cristina Bombieri, Ilaria Ferrarotti, Sara Medaglia, Carlo Agostini, Carmine Tinelli, Giovanni Malerba, Natalia Carrabino, Anna Beretta, Lucio Casali, Ernesto Pozzi, Pier Franco Pignatti, Gianpietro Semenzato, Maria Clara Cuccia, Maurizio Luisetti

Research output: Contribution to journalArticle

Abstract

Sarcoidosis is likely to result from exposure of genetically susceptible hosts to environmental agents. Erythrocyte (E) complement receptor 1 (CR1) is a membrane protein mediating the transport of immune complexes (ICs) to phagocytes, and at least three polymorphisms on the CR1 gene are related to erythrocyte surface density of CR1 molecules, in turn related to the rate of IC clearance from circulation. We hypothesized that sarcoidosis could be associated with increased frequency of the CR1 gene alleles coding for reduced CR1/E ratio. We studied 91 sarcoid patients and two control groups: 94 healthy volunteers and 71 patients with chronic obstructive pulmonary disease (COPD). Three polymorphic sites of CR1 gene, His1208Arg, intron 27 HindIII/RFLP, and Pro1827Arg, were analyzed. The three polymorphisms were in linkage disequilibrium. The GG genotype for the Pro1827Arg (C 5507G) polymorphism was significantly associated with sarcoidosis in comparison to both control groups (odds ratio [OR] = 3.13; 95% confidence interval [CI] 1.49-6.69 versus healthy control subjects, and OR= 2.82, 95% CI 1.27-6.39 versus COPD control subjects). The same genotype was particularly associated to disease in females (OR = 7.05; 95% CI 3.10-16.61 versus healthy control subjects). These findings agree with speculations on the role of CR1 gene as a possible susceptibility factor.

Original languageEnglish
Pages (from-to)17-23
Number of pages7
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume27
Issue number1
Publication statusPublished - 2002

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ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pulmonary and Respiratory Medicine

Cite this

Zorzetto, M., Bombieri, C., Ferrarotti, I., Medaglia, S., Agostini, C., Tinelli, C., Malerba, G., Carrabino, N., Beretta, A., Casali, L., Pozzi, E., Pignatti, P. F., Semenzato, G., Cuccia, M. C., & Luisetti, M. (2002). Complement receptor 1 gene polymorphisms in sarcoidosis. American Journal of Respiratory Cell and Molecular Biology, 27(1), 17-23.