Complementary function of γδ T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens

Angelo Martino, Rita Casetti, Alessandra D'Alessandri, Alessandra Sacchi, Fabrizio Poccia

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells and γδ T-lymphocytes play a crucial role in the early response to microbial infections. Since both dendritic cells and γδ T-lymphocytes may be activated by specific microbial products, we analyzed their interplay in the presence of such respective ligands: lipopolysaccharide and isopentenyl-pyrophosphate. Activated γδ T-cells increased the maturational state of dendritic cells induced by lipopolysaccharide, increasing the expression of co-stimulatory and MHC class I and II molecules. IL-12 production by dendritic cells was strongly amplified in the presence of activated γδ T-cells and the Th1 polarization of naïve CD4+ T-lymphocytes was significantly increased. On the other hand, dendritic cells enhanced γδ T-cell functions induced by isopentenyl-pyrophosphate and promote their IL-2 independent proliferation through CD86 contact. Altogether, dendritic cells and γδ T-cells exert a complementary function promoting an optimal immune response to non peptidic microbial antigens.

Original languageEnglish
Pages (from-to)230-237
Number of pages8
JournalJournal of Clinical Immunology
Volume25
Issue number3
DOIs
Publication statusPublished - May 2005

Keywords

  • γδ T-lymphocytes
  • Dendritic cells
  • Isopentenylpyrophoshate
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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