Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease

Angelo Antonini, Klaus L. Leenders, Peter Vontobel, R. Paul Maguire, John Missimer, Maria Psylla, Ilonka Günther

Research output: Contribution to journalArticle

Abstract

We used PET with tracers [18F]fluorodeoxyglucose (FDG), [18F]fluorodopa (FDOPA) and [11C]raclopride (RACLO) to study striatal glucose and dopa metabolism, and dopamine D2 receptor binding, respectively, in nine patients with multiple system atrophy. Ten patients with classical Parkinson's disease were investigated with the same three PET tracers' and three separate groups, each of 10 healthy subjects, served as control populations. We found that striatal FDOPA values separated all healthy subjects from patients with parkinsonism but they were not useful in distinguishing multiple system atrophy from Parkinson's disease. Conversely, striatal RACLO as well as FDG values discriminated all multiple system atrophy from Parkinson's disease patients as well as healthy control subjects. Metabolic and receptor binding decrements in the putamen of multiple system atrophy patients were significantly correlated. Stepwise regression analysis revealed that a linear combination of putamen RACLO and FDOPA values accurately predicted clinical measures of disease severity in the multiple system atrophy group. Our findings suggest that striatal FDG and particularly RACLO are sensitive and effective measures of striatal function and may help characterizing patients with multiple system atrophy. In contrast, FDOPA measurements are accurate in detecting abnormalities of the nigrostriatal dopaminergic system but may not distinguish among different forms of parkinsonism.

Original languageEnglish
Pages (from-to)2187-2195
Number of pages9
JournalBrain
Volume120
Issue number12
DOIs
Publication statusPublished - Dec 1997

    Fingerprint

Keywords

  • Dopa metabolism
  • Dopamine D receptors
  • Glucose metabolism
  • Multiple system atrophy
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Antonini, A., Leenders, K. L., Vontobel, P., Maguire, R. P., Missimer, J., Psylla, M., & Günther, I. (1997). Complementary PET studies of striatal neuronal function in the differential diagnosis between multiple system atrophy and Parkinson's disease. Brain, 120(12), 2187-2195. https://doi.org/10.1093/brain/120.12.2187