Complete long-term response to radiotherapy of gastric early-stage marginal zone lymphoma resistant to both anti- Helicobacter pylori antibiotics and chemotherapy

P. G. Gobbi, F. Corbella, F. Valentino, M. Bergonzi, C. Sangalli, V. Perfetti, G. R. Corazza

Research output: Contribution to journalArticle

Abstract

Background: The optimal approach to patients with gastric lymphoma of extranodal mucosa-associated lymphoid tissue (MALT) that resist to anti- Helicobacter pylori (HP) eradication therapy is still to be defined. Patients and methods: From January 1997 to December 2004, we observed 24 patients affected with newly diagnosed early-stage and HP-positive gastric lymphoma of the MALT type. Five of them resisted to oral anti-HP antibiotic regimens and to subsequent one (two patients) or two (three patients) chemotherapy regimens. Age ranged between 51 and 77 years (median 70); three were females. Translocation (11;18) was ascertained in one subject. They were admitted to local radiation therapy with a total dose of 30 Gy. Results: All such resistant patients achieved complete remission after radiotherapy. No relapses were observed after 21, 45, 48, 52, and 67 months of uninterrupted follow-up. Early toxicity was very low and consisted of mild nausea. Late toxicity or secondary malignancy was not recorded so far. Conclusions: Radiotherapy proved to be effective and safe for early-stage HP-positive gastric extranodal lymphoma of MALT type that is resistant to anti-HP eradication antibiotics and to following chemotherapy. Radiotherapy might be suggested as principal salvage therapy after resistance to HP eradication, instead of chemotherapy.

Original languageEnglish
Pages (from-to)465-468
Number of pages4
JournalAnnals of Oncology
Volume20
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Chemotherapy
  • Gastric MALT lymphoma
  • Helicobacter pylori
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Hematology

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