Complete remission of brain metastases in three patients with stage IV melanoma treated with BOLD and G-CSF

Ugo Bottoni, Paola Bonaccorsi, Valeria Devirgiliis, Vincenzo Panasiti, Riccardo Giovanni Borroni, Guido Trasimeni, Rita Clerico, Stefano Calvieri

Research output: Contribution to journalArticlepeer-review


Background: Brain metastases are the most life-threatening among the secondary localizations of melanoma for their unresponsiveness to the surgical, radiotherapeutic and/or chemotherapeutic treatments. Methods: Accidentally, we observed a complete response (CR) in a patient undergoing chemotherapy with bleomycin, vincristine or Oncovin, CCNU or lomustine, dacarbazine (BOLD) regimen for metastatic melanoma including brain metastases, who was also treated with G-CSF to manage a concomitant leukopenia. After this observation, seven more patients with stage IV melanoma with brain metastases were treated with BOLD regimen repeated every 6 weeks with administration of G-CSF in the intervals. Results: Three patients presented CR (37.5%). Two patients stopped the treatment after two courses for evident progressive disease (25%). The other three patients showed stable disease (SD: 37.5%). Median duration of SD was 24 weeks. Among the eight patients, six (75%) achieved clinical benefit. Median time to progression was 8.5 months (range 0-74+ months). Median survival was 12.5 months (range 4-74+ months). Two patients are still alive and disease-free after 74 and 57 months, respectively. Conclusion: We believe that the brilliant CR, the long duration of the disease-free intervals and the long survival in at least three of eight patients should encourage further research on BOLD with G-CSF for the treatment of advanced melanoma.

Original languageEnglish
Pages (from-to)507-513
Number of pages7
JournalJapanese Journal of Clinical Oncology
Issue number9
Publication statusPublished - Sep 2005


  • BOLD
  • Brain metastases
  • G-CSF
  • Melanoma
  • Polychemotherapy

ASJC Scopus subject areas

  • Oncology


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