Complete remission of multicentric castleman’s disease developed in a HIV+ patient after the start of HAART

Alessandro Perretti, Valentina Zuccaro, Antonello Malfitano, Giuseppe Barbaro, Giorgio Barbarini

Research output: Contribution to journalArticlepeer-review

Abstract

In August 2010, we diagnosed a Multicentric Castleman’s Disease (MCD) in a HIV+ patient with generalized lymphadenopathy, splenomegaly and pericardial effusion. A few days before the onset of symptoms, the patient had started anti-retroviral therapy with Abacavir/Lamivudine (ABC/3TC) +Ritonavir-boosted Atazanavir (ATV/r). During the hospitalization he developed a severe pancytopenia with liver failure, and he started immediately the Therapy with steroids, Ganciclovir, and Rituximab. At the 46 months follow-up, the patient is asymptomatic, his biochemical values are essentially normal with a complete regression of the superficial and deep lymphadenopathies.

Original languageEnglish
JournalJournal of AIDS and Clinical Research
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 1 2014

Keywords

  • Castleman disease
  • HHV8
  • Lymphomas AIDS related Lympho proliferative disorders in HIV
  • Therapy of castleman disease

ASJC Scopus subject areas

  • Infectious Diseases
  • Dermatology
  • Immunology
  • Virology

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