Complete resolution of hepatic aspergillosis after non-myeloablative hematopoietic stem cell transplantation in a patient with acute myeloid leukemia

Giuseppe Marotta, Monica Tozzi, Simona Sammassimo, Marzia Defina, Donatella Raspadori, Alessandro Gozzetti, Francesco Lauria

Research output: Contribution to journalArticle

Abstract

Fungal infections due to Aspergillus are a frequent cause of transplant-related mortality. For this reason, leukemic patients with severe fungal infection are usually excluded from conventional allotransplantation. Recently, some authors suggested a role for non-myeloablative hematopoietic stem cell transplantation (HSCT) in this subset of patients. We used this therapeutic approach in a patient with high-risk acute myeloid leukemia in second complete remission (CR) with pre-existing hepatic aspergillosis refractory to conventional anti-fungal therapy. A complete regression of hepatic lesions was observed after 3 months from allogeneic stem cell transplantation. Our work confirms previous reports suggesting that non-myeloablative HSCT is effective in patients not eligible for conventional transplantation because of invasive aspergillosis.

Original languageEnglish
Pages (from-to)383-386
Number of pages4
JournalHematology
Volume10
Issue number5
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Acute myeloid leukemia
  • Aspergillosis
  • Non-myeloablative hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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