Complete response as an intermediate end point in patients receiving salvage systemic therapy for urothelial carcinoma

Guru Sonpavde, Gregory R. Pond, Jonathan E. Rosenberg, Dean F. Bajorin, Ashley M. Regazzi, Toni K. Choueiri, Angela Q. Qu, Guenter Niegisch, Peter Albers, Andrea Necchi, Giuseppe Di Lorenzo, Ronan Fougeray, Robert Dreicer, Yu Hui Chen, Yu Ning Wong, Srikala S. Sridhar, Yoo Joung Ko, Matthew I. Milowsky, Matthew D. Galsky, Joaquim Bellmunt

Research output: Contribution to journalArticlepeer-review

Abstract

Background The complete remission (CR) rate with salvage systemic therapy for urothelial carcinoma (UC) is unclear, and its value as an intermediate end point and association with survival are unknown. Materials and Methods Data from phase II trials of salvage chemotherapy and/or biologic agents were pooled. Data regarding response, overall survival (OS), progression-free survival (PFS), time from prior chemotherapy, hemoglobin, performance status, and liver metastasis status were collected. Cox proportional hazards regression was used to evaluate the association of CR and other prognostic factors with outcomes. Results A total of 789 of 818 patients enrolled in 12 phase II trials had evaluable data. CR and partial response were seen in 14 (1.8%) and 109 (13.8%) patients. Median (95% confidence interval) OS for those with a CR was 21.5 (14.2-34.3) months, compared with 6.7 (6.0-7.0) months in those without a CR (P

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalClinical Genitourinary Cancer
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Advanced urothelial carcinoma
  • Complete response
  • Overall survival
  • Partial response
  • Progression-free survival
  • Salvage systemic therapy

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Medicine(all)

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